OBJECTIVE Current drug therapies for generalized anxiety disorder have limitations. In a controlled trial, the novel agent pregabalin was studied for the treatment of patients with generalized anxiety disorder. METHOD In this double-blind study, patients with DSM-IV generalized anxiety disorder were randomly assigned to receive pregabalin (150 mg/day or 600 mg/day), lorazepam (6 mg/day), or p...

Background: Alcohol abuse is common in the patients with head and neck cancer. Sudden postoperative alcohol cessation can cause withdrawal syndrome (AWS). So far, there are no studies evaluating safety efficacy of dexmedetomidine (DEX) lorazepam on AWS treatment.

BACKGROUND AND METHODS Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year randomized, double-blind, multicenter trial of four intravenous regimens: diazepam (0.15 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per kilogram), phenobarbital (15 mg ...

1879 Antiemetic prophylaxis with high dose metoclopramide or lorazepam in vomiting induced by chemotherapy Emesis induced by cytotoxic agents is an important side effect that may determine a patient's acceptance of cancer chemotherapy and may be responsible for his defaulting from potentially effective treatment. Despite the availability of several antiemetic drugs, this complication is general...

Aside from their pharmacokinetic properties, e.g. their speed of action and the duration of residual effects, benzodiazepines are still considered as equivalent in terms of their effects on cognition. Here we review evidence suggesting that certain benzodiazepines, especially lorazepam, differ in a number of respects, in particular with respect to their effects on cognition. We focus this revie...

BACKGROUND Acute alcohol withdrawal syndrome (AAWS) is encountered in patients presenting acutely to the Emergency Department (ED) and often requires pharmacologic management. OBJECTIVE We investigated whether a single dose of intravenous (i.v.) phenobarbital combined with a standardized lorazepam-based alcohol withdrawal protocol decreases intensive care unit (ICU) admission in ED patients w...

Anxiolytic drugs often have sedative effects that impair the ability to drive. Our double-blind, randomized crossover trial investigated effect of Silexan, a non-sedating, anxiolytic herbal medicinal product, on driving performance in healthy volunteers. Part 1 aimed at demonstrating equivalence between 80 mg/d Silexan and placebo. 2 was performed demonstrate superiority 160 320 mg over lorazep...

Objective To investigate the evidence-based treatment of catatonia in adults. The secondary aim is to develop a treatment protocol. Materials and methods A systematic review of published treatment articles (case series, cohort or randomized controlled studies) which examined the effects of particular interventions for catatonia and/or catatonic symptoms in adult populations and used valid out...

A new liquid chromatography-tandem mass spectrometry method has been developed and validated for the determination of alprazolam in human plasma, using lorazepam as internal standard. Detection was performed using positive ion electrospray tandem mass spectrometry on an Agilent 1200 Triple Ouad 6410A system. The mass transition ion-pair was followed as m/z 309→ 281 for alprazolam and m/z 321→ 2...

Our knowledge about the mechanisms of human motor cortex facilitation induced by repetitive transcranial magnetic stimulation (rTMS) is still incomplete. Here we used pharmacological conditioning with carbamazepine, dextrometorphan, lorazepam, and placebo to elucidate the type of plasticity underlying this facilitation, and to probe if mechanisms reminiscent of long-term potentiation are involv...