Non-parametric tests that deal with two samples include scores tests (such as the Wilcoxon rank sum test, normal scores test, log istic scores test, Cauchy scores test, etc.) and Fisher’s randomization test. B ecause the non-parametric tests generally require a large amount of computational work, there are few studies on small-sample properties, although asymptotic properties with regard to var...

Previous methods proposed for the detection of cancer driver mutations have been based on the estimation of background mutation rate, impact on protein function, or network influence. In this paper, we instead focus on those factors influencing patient survival. To this end, an approximation of the log-rank test has been systematically applied, even though it assumes a large and similar number ...

Letting ) (i S be the i-th largest city in a country, it is often observed that i S i log log 1 0 ) ( α α + ≈ for some 0 0 > α and 0 1 < α . It is called rank size rule when 1 1 − = α . This relationship has been examined by means of ordinary least squares estimation and t test in the literature. However, since ) (i S is heteroskedastic and autocorrelated, t statistics do not have standard dist...

Gu and Zheng (1993) established a Bartlett adjustment for the partial likelihood ratio test in the Cox proportional hazards regression model. It is known that the same method of adjustment cannot be used to improve the accuracy of the test statistic derived by Rao’s score method. In this paper, the method of Cordeiro and Ferrari (1991) is used to derive a Bartlett type correction for the score ...

INTRODUCTION AND AIMS the precise role of parenteral nutrition in the management of oncologic patients with intestinal occlusion is not well defined yet. We aimed to identify the effects of parenteral nutrition in these patients regarding prognosis. MATERIAL AND METHODS 55 patients with intestinal occlusion and peritoneal carcinomatosis were included. Parenteral nutrition aimed at 20-35 kcal/...

Background and Objectives: To evaluate the predictive factor for and patterns of distant metastasis in patients with rectal adenocarcinoma receiving total mesorectal excision (TME). Methods: We enrolled 217 consecutive patients who had histologically confirmed rectal adenocarcinoma and underwent surgery at Taipei Medical University- Wanfang Hospital between January 2000 and December 2014. TME w...

IL-1a, an important regulator of immune and inflammation responses, has been implicated in cancer development and prognosis. An insertion (Ins)/deletion (Del) polymorphism (IL-1a rs3783553) in the 3' UTR of IL-1a may disrupt a binding site for miRNA-122 and may affect its transcription level. Thus, this polymorphism may cause interindividual variation in immune and inflammation responses and th...

Patients with small cell lung carcinoma (SCLC) present neuroendocrine (NE) properties and chromogranin A (CGA), synaptophysin (Syn), and neural cell adhesion molecule 1 (NCAM1) are known as NE diagnostic markers, while the predictive value of the NE differentiation in SCLC remains uncertain. The aim of this retrospective study was to evaluate the prognostic significance of NE markers in tissue ...

Abstract Background To investigate the effect of nicergoline on rate complete corneal ulcer reepithelialization (CCUR) in diabetic rats with keratopathy. Methods Forty-eight streptozotocin-induced were randomly divided into two groups. The experimental group ( n = 24) received (10 mg.kg − 1 .day ), while control (n a placebo. A epithelial defect was induced using diamond burr, and area compared...