Approximately 4% of English-speaking children are affected by specific language impairment (SLI), a disorder in the development of language skills despite adequate opportunity and normal intelligence. Several studies have indicated the importance of genetic factors in SLI; a positive family history confers an increased risk of development, and concordance in monozygotic twins consistently excee...

BACKGROUND Arterial stiffness and mean arterial pressure variably contribute to systolic hypertension and increased cardiovascular risk. However, few prior community-based studies have evaluated the genetics of arterial stiffness and separate mean and pulsatile components of blood pressure. METHODS AND RESULTS Using arterial tonometry, we evaluated heritability and linkage of forward and refl...

A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing ag...

Datasets in the LOD cloud are far from being static in their nature and how they are exposed. As resources are added and new links are set, applications consuming the data should be able to deal with these changes. In this paper we investigate how LOD datasets change and what sensible measures there are to accommodate dataset dynamics. We compare our findings with traditional, document-centric ...

We present a dynamic system that allows to alter the Level of Detail (LOD) of a treecut-based object. The adaptation and selection is made in a parallel process which avoids stalling or locks because of expensive calculations and LOD changes. We present a method to control the exchange between the independent threads. Based on this separation, we present multiple strategies to perform the LOD-s...

BACKGROUND AND PURPOSE Taking advantage of low genetic variations in northern Sweden, we performed a genome-wide linkage scan to investigate the susceptibility loci for common forms of stroke. METHODS Fifty-six families, containing multiple cases of stroke and whose data had been previously used to replicate linkage to the phosphodiesterase 4D locus on chromosome 5q, were genotyped in a genom...

BACKGROUND Currently, there is an uncertainty about the impact of laparoscopic ovarian drilling (LOD) on the natural history of polycystic ovarian syndrome (PCOS). This longitudinal follow-up study was undertaken to investigate the long-term effects of LOD. METHODS The study included 116 anovulatory PCOS women who underwent LOD between 1991 and 1999 (study group) and 34 anovulatory PCOS women...