Dietz, V., and Susan J. Harkema. Locomotor activity in spinal cord-injured persons. J Appl Physiol 96: 1954–1960, 2004; 10.1152/japplphysiol.00942.2003.— After a spinal cord injury (SCI) of the cat or rat, neuronal centers below the level of lesion exhibit plasticity that can be exploited by specific training paradigms. In individuals with complete or incomplete SCI, human spinal locomotor cent...

Repeated administration of many addictive drugs leads to a progressive increase in their locomotor effects. This increase in locomotor activity often develops concomitantly with increases in their positive-reinforcing effects, which are believed to contribute to the etiology of substance use disorders. The purpose of this study was to examine changes in sensitivity to the locomotor effects of o...

The effect on locomotor activity of in vivo activation of metabotropic glutamate receptors (mGluRs) in the nucleus accumbens (NAcc) was investigated in rats. Bilateral intracranial microinjections into the NAcc of the selective mGluR agonist, 1-aminocyclopentane-trans-1,3-dicarboxylic acid [(1S,3R)-ACPD], were made in the freely moving rat and locomotor activity was subsequently measured for 2 ...

Introduction: The weight-loss drugs can induce depression. Orlistat is one of the common drugs, but preclinical studies about its effect on mood have not been performed. aim this study was evaluating orlistat alone and following inducing stress mice depressive behavior.
 Methods: In fundamental-applied study, male white (27±2 g), in six groups having 7 animals were used. administered orall...

Although recent vertebrate studies have revealed that different spinal networks are recruited in locomotor mode- and speed-dependent manners, it is unknown whether humans share similar neural mechanisms. Here, we tested whether speed- and mode-dependence in the recruitment of human locomotor networks exists or not by statistically extracting locomotor networks. From electromyographic activity d...

PEDALING-RELATED BRAIN ACTIVATION IN PEOPLE POST-STROKE: AN FMRI STUDY Nutta-on Promjunyakul, P.T., M.Sc. Marquette University, 2012 This study aimed to enhance our understanding of supraspinal control of locomotion in stroke survivors and its relationship to locomotor impairment. We focused mainly on the locomotor component of walking, which involves rhythmic, reciprocal, flexion and extension...

The trunk plays a pivotal role in limbed locomotion. Yet, little is known about how the brain stem controls trunk activity during walking. In this study, we assessed the spatiotemporal activity patterns of axial and hindlimb motoneurons (MNs) during drug-induced fictive locomotor-like activity (LLA) in an isolated brain stem-spinal cord preparation of the neonatal mouse. We also evaluated the e...

A series of experiments examined the ability of dopamine D3/D2 receptor agonists [(+)-(4aR,10bR)-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]b enzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride (PD 128,907), (+/-)-7-hydroxy-dipropylaminotetralin hydrobromide (7-OH-DPAT), quinpirole and bromocriptine] to produce a variety of dopaminergically mediated behaviors. The effects of these drugs with selectiv...

Previous studies of the in vitro neonatal rat brain stem-spinal cord showed that propriospinal relays contribute to descending transmission of a supraspinal command signal that is capable of activating locomotion. Using the same preparation, the present series examines whether enhanced excitation of thoracic propriospinal neurons facilitates propagation of the locomotor command signal in the le...

The influence of adenosine receptor agonists and antagonists on cocaine-and amphetamine-induced hyperactivity was examined in mice. All adenosine receptor agonists significantly decreased the locomotor activity in mice, and the effects were dose-dependent. It seems that adenosine A1 and A2 receptors might be involved in this reaction. Moreover, all adenosine receptor agonists: 2-p-(2-carboxyeth...