Conflicting views exist at the present regarding the influences of a deep saturation dive on liver function in divers. Therefore, we first reevaluated whether a deep saturation dive (400 msw) induces a hepatic disturbance. As the result, plasma activities of both transaminases (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) increased significantly, whereas cholinesterase (...

Pediatric obesity has increased dramatically all over the world and nonalcoholic fatty liver disease (NAFLD) is one of the most frequent complications associated with excess adiposity. NAFLD causes serum transaminase elevation and liver disease, which could end up in fibrosis, cirrhosis and eventually hepatocellular carcinoma. NAFLD seems to be associated with the metabolic complications of obe...

One hundred and one patients (51 females and 50 males), presenting with unexplained hepatomegaly were investigated. The histological findings on liver biopsy included normal architecture (36), changes of viral hepatitis (5), round cell infiltration in portal tract (10), fatty changes (14), hepatic malignancy (8), biliary disease (3), infections of the liver (12), cirrhosis of liver (6) and a mi...

Among 82 patients with brucellosis, physical and/or biochemical abnormalities suggesting liver disease were found in 40 cases. A soft and tender liver enlargement was present in 65 % of them, and the spleen was palpable in 52%. The most frequent biochemical abnormalities were a slight increase of serum transaminases and alkaline phosphatase. Liver biopsy showed a non-specific reactive hepatitis...

The following is the case of a 61-year-old man who had a liver transplant due to alcoholic liver disease in February 2011. He presented with a two-week history of fever and diarrhea, with continuous hypotension and with no additional pathological products. Laboratory tests showed the presence of leukocytosis, a marked increase of transaminases and deterioration of liver function. An abdominal C...

Autoimmune hepatitis (AIH) is a severe type of chronic liver disease. The lack of appropriate animal models has resulted in a limited understanding regarding the etiology of AIH. Here, we demonstrated that mice deficient in Tyro3, Axl and Mer (TAM) receptor tyrosine kinases (RTKs) developed persistent inflammatory liver damage resembling AIH. Tyro3(-/-)Axl(-/-)Mer(-/-) triple mutant (TAM(-/-)) ...

hepatoprotective efficacy of propolis extract (honeybee hive product, 200 mg/kg, p.o.) was studied against carbon-tetrachloride-(ccl 4, 0.15 ml/kg, i.p.) induced biochemical and histopathological changes. silymarin, a known hepatoprotective drug was used as a positive control. subchronic exposure to ccl 4 for 3 weeks (5 days a week) caused sharp elevation in the activity of liver enzymes i.e. ,...

Monocrotophos administration at intervals induced variable responses in phosphatases, transaminases and aldolase of liver and plasma. Hepato-toxicity was aggravated under protein deficient state. A weak resistance to toxicity was observed in rats on low protein diet (5%). However, animals fed on protein enriched diet (20%) indicated an elevation in tissue defense mechanism and were able to comb...

Among 82 patients with brucellosis, physical and/or biochemical abnormalities suggesting liver disease were found in 40 cases. A soft and tender liver enlargement was present in 65 % of them, and the spleen was palpable in 52%. The most frequent biochemical abnormalities were a slight increase of serum transaminases and alkaline phosphatase. Liver biopsy showed a non-specific reactive hepatitis...