The use of extracorporeal pig liver perfusion for temporary liver support has been followed not infrequently by major bleeding with a fall in coagulation. factors and platelets, rather than a rise as hoped. In 18 experimental perfusions in which 1251-labelled fibrinogen was used as a marker there was in every instance a significant loss of the fibrinogen into the fluid supporting the liver in t...

Imaging methods to evaluate hepatic microcirculation (HM) and liver function (LF) by directly monitoring overall liver tissue remain lacking. This study establish imaging methods for LF that combines Laser speckle perfusion imaging (LSPI) and in vivo optical imaging (IVOI) technologies to investigate changes of hepatic microcirculation and reserve function in the animals gavaged with 50% ethano...

The current challenge in the field of thermo-ablative treatments tumors is to achieve a balance between complete destruction malignant cells and safeguarding surrounding healthy tissue. Blood perfusion plays key role for thermal ablation success, especially case highly vascularized organs like liver. This work aims at monitoring temperature within perfused swine liver undergoing laser (LA). Tem...

background: hepatic ischemia/reperfusion injury (i/ri) is a multifactorial pathophysiologic process which can lead to liver damage and dysfunction. this study examined the protective effect of dexamethasone on the gene expression of endothelial nitric oxide synthase (enos) and endothelin-1 (et-1) and on the liver tissue damage during warm hepatic i/r. methods: a total of 32 male wistar rats was...

We report the case of a 67-year-old man with remnant left liver torsion causing acute hepatic venous outflow obstruction after right hepatectomy for giant hepatocellular carcinoma, which was successfully treated with surgery. After the primary surgery, he developed significant liver dysfunction and renal failure. Doppler ultrasonography disclosed gradual reduction of hepatic perfusion. Abdomina...

The effects of infusion of adrenaline and noradrenaline were studied in rats with intrahepatic tumors, using 99nTcand 51Crlabeled microspheres. The effect on general circulation, car diac output, and tissue blood flow was pronounced, especially with infusion of noradrenaline. Studies of liver tumor perfusion ¡nrelation to surrounding liver parenchyma perfusion showed an increased tumor/liver r...

PURPOSE To investigate the value of perfusion-weighted MRI in the evaluation of the intranodular hemodynamic characteristics of dysplastic nodules (DNs) and hepatocellular carcinomas (HCCs) in an experimental rat model. MATERIALS AND METHODS A total of 40 rats with chemically-induced DNs and HCCs were investigated. Single-slice gadolinium-enhanced perfusion-weighted MRI was performed to evalu...

UNLABELLED In aggregate, livers donated after circulatory death (DCD) provide lower rates of graft and patient survival compared to brain dead donors (DBD). A method to identify DCD livers likely to perform well would lead to better decision-making regarding which livers to use and which to discard and is an important unmet clinical need. We hypothesized that the ischemic time between extubatio...