Primary immunodeficiency disorders can predispose to certain malignancies but hitherto no such relation has been established for X-linked agammaglobulinaemia (XLA). We have diagnosed rapidly progressive colorectal cancer in 3 unrelated young adults with XLA. We could find no explanation for the tumours. Since the calculated incidence of rectosigmoid cancer is increased 30-fold in patients with ...

We undertook this study to determine whether patients with late-onset hypogammaglobulinemia, who are at very high risk for gastric cancer, have a reduced secretion of gastrin after stimulation with food or bombesin, a potent gastrin-releasing stimulus. We compared the plasma gastrin responses to bombesin and to a standard test meal in 18 patients with late-onset hypogammaglobulinemia with those...

We report on a case of bacteremia caused by a previously unknown urease-negative Helicobacter strain, IMMIB HP-28/08, isolated from blood cultures of a 28-year-old man with X-linked agammaglobulinemia. The identification of the isolate was based on 16S rRNA gene sequencing. In the phylogenetic tree, the isolate fell into a cluster which included Helicobacter canadensis, Helicobacter equorum, an...

Besides the conventional D5h(8149)-C70 fullerene, there are a large number of C70 isomers that violate the isolated pentagon rule (IPR). However, these non-IPR C70 fullerenes have been less investigated owing to their low stabilities or high reactivities. In this study, we report for the first time the X-ray structure of an unconventional endohedral C70 fullerene, Sc2O@C2(7892)-C70. The combine...

Activated platelets release a potent inhibitor of factor Xla previously identified as a Kunitz proteinase inhibitor domaincontaining form of the p-amyloid precursor proteins (pAPP). Two carboxy-terminal truncated forms of the pAPP, pAPP751 and pAPP-770. are shown to be the predominant isoforms secreted by platelets. The release of pAPP from platelets is responsible for the higher concentration ...