fourier transformed infrared spectroscopy (ftir) has extensively been used for biological applications. cisplatin is one the most useful antineoplastic chemotherapy drugs for a variety of different human cancers. one of the clinical problems in its application, which would consequently affect the therapeutic outcome of its application, is the occurrence of resistance to this agent. in this proj...

background: activation of the ubiquitin-proteasome pathway in various malignancies, including colorectal cancer, is established. this pathway mediates the degradation of damaged proteins and regulates growth and stress response. the novel human gene, ube2q2, with a putative ubiquitin-conjugating enzyme activity, is reported to be overexpressed in some malignancies. we sought to investigate the ...

objective: mir-302-367 is a cluster of polycistronic micrornas that are exclusively expressed in embryonic stem (es) cells. the mir-302-367 promoter is functional during embryonic development but is turned off in later stages. motivated by the cancer stem cell hypothesis, we explored the potential expression of mir-302 in brain tumor cell lines. materials and methods: in the present experimenta...

there is a high degree (>95%) of intraspecies similarity in the coat protein (cp) amino acid sequences within passionfruit woodiness virus (pwv) and cucumber mosaic virus (cmv), both infecting passionfruit vine in new south wales. on this basis, a dual transgene containing the translatable cdnas coding for the cps of pwv and cmv was constructed in the binary vector pbi121 and used for transform...

Background: It is now well-demonstrated that histone demethylases play an important role in developmental controls, cell-fate decisions, and a variety of diseases such as cancer. Lysine-specific demethylase 5D (KDM5D) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl H3K4 at the start site of active genes. In this light, the aim of this study was to invest...

drought causes significant reductions in crop productivity in many parts of the world, including iran. identifying genotypes tolerant to drought stress is therefore one of the foremost goals of crop breeding programs. this study investigated the effect of terminal drought stress on yield and yield components of new winter rapeseed lines, and identified new winter rapeseed lines tolerant to term...

the selection of high yielding varieties with good stability‏ ‏is an important objective in rice breeding ‎programs. the grain yield of eight rice lines with a check (nemat) were compared‎‏ ‏on six locations of gilan ‎and mazandaran provinces during two years, using rcbd with four replications. combined analysis of ‎variance showed that the effect of variety and year ‎‏×‏‎ location ‎‏×‏‎ variet...

determining general and specific combining ability of lines is necessary to use them as parents of hybrid varieties. in addition, estimates of the heritability of characters helps in selecting suitable breeding methods and predicting genetic gains of the traits. to determine general and specific combining abilities and gene effects of agronomic characters, five cms lines and four restorer lines...