Abstract Objective To investigate the response of infrapatellar fat pad (IFP) to running at different intensities and further explore underlying mechanisms these responses under running-induced loadings. Methods Animals were randomly assigned into sedentary (SED), low-intensity (LIR), medium-intensity (MIR), high-intensity (HIR) groups. The rats in LIR, MIR, HIR groups subjected an 8-week tread...