BACKGROUND Medial temporal lobe epilepsy (MTLE) is associated with limbic atrophy involving the hippocampus, peri-hippocampal and extra-temporal structures. While MTLE is related to static structural limbic compromise, it is unknown whether the limbic system undergoes dynamic regional perfusion network alterations during seizures. In this study, we aimed to investigate state specific (i.e. icta...

Exposure to adversity early in life is associated with the development of a range of psychiatric disorders in adulthood. Accumulating evidence suggests that pre-puberty is a time of enhanced vulnerability to environmental insults, and that prepubertal stress may alter normal brain maturation. In this review, I consider the long-term consequences of pre-pubertal stress on brain and behaviour in ...

or metabolites. The presence of anti-neural antibodies in patients with pns has led to the suggestion that the associated neurologic symptoms are a result of antibody-induced inflammatory reactions3. Because of the infrequent incidence of ple, there is a paucity of literature discussing its diagnosis and management. Here, we describe a case of ple in a male patient, and we discuss the syndrome’...

Areas of the brain's left hemisphere involved in retrieving words with emotional connotations were studied with fMRI. Participants silently generated words from different semantic categories which evoked either words with emotional connotations or emotionally neutral words. Participants repeated emotionally neutral words as a control task. Compared with generation of emotionally neutral words, ...