The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...

background : acanthamoeba castellanii forms a resistant cyst that protects the para-site against the host’s immune response. acanthamoeba type-i metacaspase (acmcp) is a caspase-like protein that has been found to be expressed during the encysta-tions. dictyostelium discoideum is an organism closely related to acanthamoeba useful for studying the molecular function of this protozoan caspase-lik...