in 1996 grinspan et al presented the association between primary hypertension and diabetes mellitus as grinspan syndrome. through various studies, researchers have noticed that epidermal lichen planus cells show enzymatic disorders as well as defective carbohydrate expression. therefore, it was assumed that there is a relationship between cells and hormones in metabolic actions. besides, some r...

BACKGROUND Lichen planus is recognized as an inflammatory disease of the skin with different morphologic patterns. Different treatment modalities, including topical and systemic corticosteroids, methotrexate, cyclosporine, azathioprine, topical calcineurin inhibitors, and psoralen plus UVA (PUVA), have been suggested for lichen planus. Although the efficacy of narrowband UVB (NBUVB) for treatme...

Actinic lichen planus (ALP) is a distinct variant of lichen planus mainly involving teenagers with an Asian racial profile. Three clinical types of ALP have been described: annular, pigmented, and dyschromic. We report an ALP with unusual presentation in a 56-year-old woman with no relevant medical history, which was clinically suggestive of actinic keratosis. Histological findings refined the ...

Background: Lichen planus has various clinical and epidemiologic features in different countries. Objectives: To determine clinical and epidemiologic patterns of lichen planus in dermatology department of Hamadan Sina Hospital during a ten-year period. Patients and Methods: This retrospective descriptive study was performed on 363 patients (Including 190 females and 173 males) suffered fr...

A 50-year-old man and 71-year-old woman presented to our clinic with unilateral, linear, erythematous, pruritic lesions along the lines of Blaschko. On the basis of clinical and histopathological findings, the lesions were diagnosed as lichen planus with a Blaschkoian distribution, which is a rare form of lichen planus. The patients were treated with topical corticosteroids and antihistamines.

The issue as to whether oral lichen planus is a premalignant disorder is still controversial. This study aimed to examine oral malignancies associated with oral lichen planus and to investigate whether oral lichen planus has an intrinsic malignant potential or whether there are also contributing external risk factors. A retrospective cohort study in 200 Caucasian patients with oral lichen planu...

Lichen planus pigmentosus (LPP) is a variant of lichen planus. It characterized by small black, brown macules, on sun exposed areas like face, neck, upper extremities and trunk. Lesions are insidious in onset with gradually progressive course. Few variants have been reported LPP inversus, localized LPP, linear zosteriform oral mucosa etc. Here, we present case young adolescent male, which rare ...

BACKGROUND Topical tacrolimus has been reported to be an effective treatment for genital lichen planus in small case series. We retrospectively reviewed the medical records of 16 patients with symptomatic vulvar lichen planus who received treatment with tacrolimus ointment. OBSERVATIONS All patients had symptomatic vulvar lichen planus recalcitrant to other treatments. Of 16 patients, 15 (94%...