نتایج جستجو برای: lewis rat
تعداد نتایج: 291809 فیلتر نتایج به سال:
Chronic kidney disease (CKD) is associated with sympathetic hyperactivity and impaired blood pressure control reflex responses, yet direct evidence demonstrating these features of autonomic dysfunction in conscious animals is still lacking. Here we measured renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) using telemetry-based recordings in a rat model of CKD, the Lewis ...
diffusion flame in a dust cloud combustion in a counterflow configuration is investigated in this research. it is presumed that the fuel particles vaporize first to yield a gaseous fuel to oxidize with the gas phase. the reaction rate is assumed to be of the arrhenius type. conservation equations for the non-unity lewis number are solved and the flame temperature with the variations of differen...
BACKGROUND A previous study using an intercross between the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) identified a locus on chromosome 4, named Anxrr16, influencing an experimental index of anxiety and showing a transgressive effect, with alleles from the LEW strain (more anxious) decreasing rather than increasing anxiety. OBJECTIVE To confirm the location and i...
Rheumatoid arthritis (RA) is a chronic inflammatory disease that produces synovial proliferation and joint erosions. The pathologic lesions of RA are driven through the production of inflammatory mediators in the synovium mediated, in part, by the transcription factor NF-kappaB. We have identified a non-steroidal estrogen receptor ligand, WAY-169916, that selectively inhibits NF-kappaB transcri...
The majority of antigenic peptides exhibit restriction in their interaction with the MHC molecules on antigen-presenting cells of different haplotypes. Certain peptides, however, are "permissive': they bind strongly to different MHC molecules and are selected as the immunodominant epitopes by animals using these MHC gene products. Here we show for the first time that several peptides from four ...
PURPOSE The immunosuppressive effects of FK506 on allogeneic corneal transplantation were tested in a rat model. METHODS Inbred-strain Lewis rats were used as recipients, and Fisher rats were used as donors. Intraperitoneal injection of FK506 (0.3, 1.0, and 3.0 mg/kg per day) was administered for 2 weeks, and the grafts were inspected by clinical evaluation. Mixed lymphocyte culture assay, us...
BACKGROUND To refine facial transplantation techniques and achieve sound results, it is essential to develop a suitable animal model. Rat is a small animal and has many advantages over other animals that have been used as transplantation models. The purpose of this study was to describe a rat hemifacial transplantation model and to verify its convenience and reproducibility. METHODS Animals u...
Previously, we demonstrated that skeletal mass, structure and biomechanical properties vary considerably among 11 different inbred rat strains. Subsequently, we performed quantitative trait loci (QTL) analysis in four inbred rat strains (F344, LEW, COP and DA) for different bone phenotypes and identified several candidate genes influencing various bone traits. The standard approach to narrowing...
Mislabelling of Donryu Rats To the Editor: Between 1992 and 2000, 21 papers1-21 were published that used rats from inbred colonies in Melbourne and Tokyo that were believed to be of the Donryu (DRY) strain. These rats were thought to have been the same strain as DRY used by Dr Tanase in early breeding experiments in relation to blood pressure in spontaneously hypertensive rats (SHR).22,23 The o...
multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae), are inflammatory autoimmune diseases of the central nervous system. chymotrypsin is a serine protease with immunomodulatory effect in the peripheral organs. we previously demonstrated the immunomodulatory effect of chymotrypsin in ameliorating the eae in female lewis rats. however, there are sex-based...
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