The aim of this prospective, uncontrolled clinical study was to evaluate the tolerability and the efficacy of levetiracetam as add-on treatment in 78 adults and 44 children with intractable epilepsy. The patients' seizure frequency in the 8 weeks baseline period was compared to their seizure frequency after a mean follow-up of 8 months of treatment.A greater than 50% reduction in seizure freque...

BACKGROUND Levetiracetam is used to manage status epilepticus (SE) and cluster seizures (CS) in humans. The drug might be absorbed after rectal administration and could offer a practical adjunct to rectal administration of diazepam in managing SE and CS. HYPOTHESIS Levetiracetam is rapidly absorbed after rectal administration in dogs and maintains target serum concentrations for at least 9 ho...

Objective: The objective is to shed light on the prescribing pattern of levetiracetam, a newer antiepileptic drug, in treatment different types epilepsy. Methods: A record-based cross-sectional study epilepsy patients who reported Therapeutic Drug Monitoring Unit Department Pharmacology, Regional Institute Medical Sciences, Manipur, was conducted. Case records receiving levetiracetam and report...

conclusions it became clear at the end of the study that the effectiveness of two drugs were the same and they didn’t have any meaningful difference. according to the result gained from this study, levetiracetam is a proper alternative treatment instead of sodium valproate which has appropriate effectiveness along with lower complications. results comparison of mean generalized tonic colonic at...

Levetiracetam is an active pharmaceutical ingredient widely used to treat epilepsy.

Levetiracetam is a commonly used drug in today’s world for long term management of partial as well generalized seizures mainly due its major advantage that has so few and non-threatening side effects[1].In the following case scenario, we show how 70 years old male presented with severe hyperkalemia after no other common culprits were seen, it was thought to be effect therapy levetiracetam disco...

Canine status epilepticus (CSE) is characterized by epileptic seizures that are longer than 5 min or more one seizure with incomplete recovery. Currently, diazepam suppositories generally prescribed for CSE. Levetiracetam (LEV) of the newest antiepileptic drugs currently available. This study compared pharmacokinetics intragastric and intrarectal administration in oral formula LEV four healthy ...

We report the case of a five-year-old girl, presenting with difficult-to-treat, symptomatic focal epilepsy, who developed status gelasticus following the introduction of levetiracetam as add-on treatment to oxcarbazepine and diazepam. Gelastic seizures were documented by video-EEG and were responsive to i.v. administration of diazepam. A possible causative role of levetiracetam is suggested. Sp...

BACKGROUND Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function. CASE PRESENTATION Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LE...

Late Onset Myoclonic Epilepsy in Down Syndrome (LOMEDS) is a recognized entity usually preceded by cognitive deterioration. We report two patients with LOMEDS and cognitive decline, aged 52 and 44 years. Continuous video-EEG recording showed generalised spike and slow wave complexes as an ictal correlate of the myoclonic jerks in both patients. Low dose levetiracetam resulted in rapid, sustaine...