background: ménière’s disease  has been  remained  as a difficult therapeutic  challenge. the  present  study aimed to   determine    the effects of  one-shot low-dosage intratympanic   gentamicin   on  vertigo control, auditory outcomes  and  findings of computerized  dynamic posturography  and   vestibular  evoked  myogenic potentials in patients with unilateral ménière’s disease. methods: in...

The renal excretion of gentamicin, an aminoglycoside antibiotic, was studied in the isolated perfused rat kidney (IPRK) model. Dose-linearity experiments were carried out at four doses (400, 800, 1600, 3200 μg), targeting initial perfusate levels of 5, 10, 20 and 40 μg/ml. Additionally, gentamicin was co-perfused with sodium bicarbonate (0.25 mM) and/or cimetidine (2 mM) to evaluate the effect ...

We compared the dried MicroScan microdilution panel, Synergy Quad plate agar dilution, and high-potency disk diffusion screening methods for the detection of high-level aminoglycoside resistance in 815 enterococcal bloodstream isolates. Agreement between the three methods was 99% when testing for high-level gentamicin resistance and 96% when testing for high-level streptomycin resistance.

Gentamicin nephrotoxicity limit its usage against gram negative bacteria. Most researches showed that antioxidant agents improved gentamicin nephrotoxicity. According to these investigations oxidative stress play a central role in the mechanism of gentamicin induced nephrotoxicity. Recently Rafieian-Kopaei and colleagues showed that erythropoietin significantly ameliorated serum creatinine, blo...

background and purpose: gentamicin-induced nephrotoxicity results from the production of reactive oxygen species (ros) in the kidneys, and since cinnamon has antioxidant properties, this research studied the effects of cinnamon extract on the prevention and treatment of gentamicin-induced toxicity in immature white rats.materials and methodology: in this study 36 immature female wistar rats wer...

background: enterococci are members of the normal gut flora and released into the environment via sewage outlets, where they can survive for long times. infections with high-level gentamicin resistant (hlgr) enterococci are emerg­ing worldwide. hlgr enterococci have developed a resistance to most antibiotics commonly used for enterococcal in­fec­tions therefore; treatment of infections caused b...

Enterococci infections, have drawn attention of clinicians due to rapid increase in high level aminoglycoside resistance (HLAR). This predicts failure β-lactam antibiotic and combination, which is the current treatment choice for serious enterococci infections. led us investigate about prevalence HLAR our hospital setting Shimoga, Karnataka. All clinical samples received at Microbiology laborat...