By a result of H. Cartan (cf. 5]), the homotopy of a simplicial commutative algebra is equipped with divided power operations. In this paper, we provide a general approach to the construction of Cartan operations in the context of simplicial algebras over an operad.

The models that were analyzed using FLAC version 4.0 (FLAC, 2000) are shown on Figure 5.1. The models have different soil types: loose silty sand with 20% fines content (Figures 5.1a and 5.1b), soft clay (Figure 5.1c), and silt (Figure 5.1d). Hence, the determination of the parameters is different for each model. The following sections discuss the determination of the parameters used in the ana...

Patients with advanced/metastatic gastric cancer (GC) or colorectal (CRC) have poor prognosis, so there is an unmet need for new therapeutic agents in these settings. Trophoblast cell surface protein 2 (TROP2) a transmembrane glycoprotein overexpressed many epithelial cancers, including GC and CRC. Dato-DXd antibody-drug conjugate consisting of humanised anti-TROP2 IgG1 monoclonal antibody cova...

Methotrexate can cause a range of toxicities. It is usually not life threatening in low dose even when taken for long term. Life complications are seen high methotrexate therapy which could lead to malignancies. and adverse effects be at any except nephrotoxicity most commonly treatment. This case report deals with rheumatoid arthritis on term therapy, who unknowingly took excessive dosage lead...

Impaired transport of methotrexate (MTX) is a common resistance mechanism of tumor cells to this drug. Trimetrexate (TMTX), a second-generation folate antagonist, is still active against MTX-transport-resistant cells because it enters cells by passive diffusion and does not use the reduced folate transport system for cell entry. Therefore, although leucovorin (LV) protects MTX-sensitive cells f...

Currently gemcitabine-based regimens and FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) are widely used standard for first-line treatment of patients with advanced pancreatic adenocarcinoma. Refractory patients may receive either FOLFOX (5-fluorouracil and oxaliplatin) or gemcitabine based on the first line regimen. This review is an update from the 2012 American Society o...

Abstract Background and Aims Currently, peri-operative docetaxel, oxaliplatin, leucovorin, 5-fluorouracil (FLOT) chemotherapy is the gold standard treatment for patients with locally advanced gastric cancer (LAGC), who undergo surgery. The known nephrotoxicity of both docetaxel oxaliplatin compounds may limit its application in CKD population. Nevertheless, limited evidence available regarding ...