The different leucocyte types are an important part of the immune system. Thus, they have been used in ecological studies to assess immune function and physiological stress in wild birds. It is generally assumed that increased stress and decreased condition are associated with an increase in the ratio of heterophils to lymphocytes, the H/L ratio. We studied leucocyte profiles in relation to bod...

BACKGROUND While most anaesthetics are known to suppress immune reactions, data from experimental studies indicate the enhancement of reactivity to inflammatory stimulators under xenon treatment. We investigated the effect of xenon anaesthesia on leucocyte function in surgical patients. METHODS We performed a subgroup analysis of subjects undergoing xenon or sevoflurane anaesthesia in a rando...

UTI is the most common hospital acquired infections, accounting for 35% in hospitalized patients. Early diagnosis and prompt treatment of UTI in CKD patients is necessary to prevent grievous complications. The objective of this study is to determine diagnostic accuracy of multi dipstick tests for detecting UTI in CKD population and study spectrum of UTI in CKD. CKD patients attending Nephrology...

Leucocyte ascorbic acid was measured in 3I patients who had sustained an acute myocardial infarction. Nine of the patients were seen within 6 hours of the infarction and 22 patients within 12 hours. It was found that there was a significant fall in the leucocyte ascorbic acid to scorbutic levels within I2 hours of the infarction in each case, and this occurred when the white blood cell count wa...

BACKGROUND Stromal leucocyte populations in human endometrium comprise T cells, macrophages, and phenotypically unusual endometrial granulated lymphocytes. Their proportions vary during the menstrual cycle and, in particular, endometrial granulated lymphocytes increase in number in the late secretory phase. The stimulus responsible for these cyclical changes is unknown but it is likely that the...

1. The effect of unsaturated long-chain non-esterified fatty acids (NEFA) on the human leucocyte sodiumpump was studied in vivo. 2. Plasma NEFA level was raised acutely from 0.28 (SD 0.10) to 2.54 (SD 0.48) mmol/l by infusion of 'Intralipid 20%' (trademark) at 90 ml/h with heparin, and the human leucocyte 22Na efflux rate constants were studied in eight normal weight males. 3. After 3 h, there ...

The effect of Neisseria gonorrhoeae on release of enzymes from human leucocytes was determined. Supernatants from incubation mixtures containing leucocytes and gonococci were assayed for activity of the cytoplasmic enzyme, lactic acid dehydrogenase, as well as for activity of the hydrolytic enzymes, β-glucuronidase and lysozyme, which are found primarily in leucocyte granules. Thirty-minute inc...

Labelled leucocyte imaging is an established technique for the detection of inflammation and sepsis. Of the many radioisotopes used to label leucocytes, Indiuml1 tropolonate (11 1In) and Technetium-99m hexamethyl propylene amine oxime (99mTc HMPAO) are the most widely used. Leucocytes are obtained from heparinised, peripheral venous blood (40-100 ml) and then separated from erythrocytes and pla...

AIMS To quantify a range of haematological indicators of viral infection (leucocyte apoptosis, cytopenia of normal lymphocytes, reactive lymphocyte increase, neutropenia) in patients with recent onset invasive meningococcal disease (IMD), with a view to test the association of viral infection with IMD and identify possible haematological risk factors for its development. SUBJECTS AND METHODS ...

Background and aims: Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced cortical actin reorganisation. In addition, Fer participates in cytoskeletal interactions mediated by cadherins, platelet endothelial cell adhesion molecule 1 (PECAM-1), and integrins, and has recently been implicated in limiting the innate immu...