While the efficacy and safety of topical 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% therapy has been established in Caucasian populations, those with skin types I-II, little research has focused on individuals with darker skin types. The purpose of this open-label study was to evaluate the efficacy and safety of mequinol 2%/tretinoin 0.01% solution in the treatment of solar lentigines in As...

tive, technical, and material support: Beach and Wilkinson. Study supervision: Khumalo. Financial Disclosure: None reported. Funding/Support: The original study was supported in part by the North American Hair Research Society (Dr Beach) and the Women’s Dermatologic Society (Dr Beach). Dr Wilkinson is supported by the Medical Research Council (United Kingdom) and performed the laboratory work i...

BACKGROUND It has been reported that intense pulsed light is efficacious for rejuvenation of photoaged skin, specifically the improvement of appearance of telangiectases and solar lentigines. OBJECTIVE The objective was to define the treatment variables for photodamaged facial skin using a newer intense pulsed light system. METHODS Twenty-three female subjects received three treatments usin...

Ink spot lentigoは日光黒子の稀な亜型で，露光部位に多くは孤発性に生じる小型で均一な色調の黒色斑である．51歳，skin type IIIの日本人男性に生じた1例を報告する．半年前に気づいた，背部中央の長径7 ㎜，浸潤を触れない均一な色調の黒色斑であり，ダーモスコピーでは濃褐色から黒色の定型的色素ネットワークを呈した．病理では単純黒子の所見で，延長する表皮索の先端にメラニン沈着が優位に分布するskip areaがみられた．Melan-A Giemsa染色で，メラノサイトは表皮基底層で軽度個別性に増加しているが，明らかな異型性はなかった．Ink lentigoの報告は国外では20例あり，skin I〜IIの白人に多い．自験例は本邦初であるが，周知されていないためink lentigoとして報告されていない可能性がある．本疾患は，濃い黒色調のため臨床的には表在拡大型黒色腫と...

The diagnosis of pigmented actinic keratosis can be complicated in clinical practice. The differential diagnosis with lentigo maligna melanoma can be difficult due to common clinical and dermoscopic characteristics. We present 5 cases of pigmented actinic keratosis in 4 patients. The most common dermoscopic finding was a grayish-brown granulation with a perifollicular distribution, present in a...

Linear pigmentation of the nail apparatus most reflects longitudinal melanonychia. It results either from simple activation of matrical melanocytes induced by various factors or from benign (lentigo or naevus) or malignant (melanoma) melanocyte hyperplasia. Hematomas and some fungal infections can falsely resemble linear pigmentation. Non-linear pigmented lesions of the nail bed are most often ...

Please cite this article as: Collgros H, Lamas-Doménech N. FR-Lentigo maligno, actualización en técnicas diagnósticas y terapéuticas. Actas Dermosifiliogr. 2015;106:135--136. ∗ Corresponding author. E-mail address: [email protected] (H. Collgros). Differential diagnosis includes seborrheic keratosis, solar lentigo, lichenoid keratosis, actinic keratosis, and pigmented actinic keratosis. ...

BACKGROUND Lentigo maligna (LM) is a melanoma in situ on sun-damaged skin, with a strong predilection to the head and neck area of the elderly. Many therapeutic modalities have been proposed in the treatment of this pathology, including surgery, cryotherapy, radiotherapy and topical imiquimod. Up to date surgical excision remains the treatment of choice with the lowest recurrence rate. Recently...

OBJECTIVE To investigate risk factors for lentigo maligna melanoma (LMM) compared with superficial spreading melanoma (SSM). DESIGN Population-based case-control study in Queensland, Australia. SETTING General community. PARTICIPANTS Population-based sample of 49 patients with LMM and 141 with SSM (in situ or invasive) aged 14 to 86 years at diagnosis in 1979 and 1980 and 232 control subj...