17β-estradiol (E2), the predominant and most biologically active form of estrogen has been shown to modulate various macrophage activities, sometimes with opposite effects, related to experimental conditions. The aim of this study was to investigate the effect of E2 alone or in combination with PKA inhibitor H-89 or recombinant human chorionic gonadotropin (rhCG) on leishmanicidal activity and ...

IB-01212, an antitumoral cyclodepsipeptide isolated from the mycelium of the marine fungus Clonostachys sp., showed leishmanicidal activity at a low micromolar range of concentrations on promastigote and amastigote forms of the parasite. Despite its cationic and amphipathic character, shared with other membrane active antibiotic peptides, IB-01212 did not cause plasma membrane lesions large e...

Pistacia integerrima Stew ex Brandis is a valued medicinal plant used for curing various diseases such as diarrhea, fever, liver disorder, pain, asthma, and inflammation. The aim of this study was the isolation bioactive leishmanicidal agents from methanolic extract. extract led to flavonoids 3,5,7,4/-tetrahydroxy-flavanone (1). isolated compound 1 were tested antileishmanial effect. showed per...

BACKGROUND Studies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis. Previous results from our laboratory showed a large infiltrate of neutrophils in the site of infection in a mouse strain resistant to L. (L.) amazonensis (C3H/HePas). In contrast, the susceptible strain (BALB/c) displayed a ...