The mechanisms of mitochondrial proton (H+) leak under various pathophysiological conditions are poorly understood. In the present study it was hypothesized that different mechanisms underlie H+ leak in cardiac IR (ischaemia/reperfusion) injury and IPC (ischaemic preconditioning). Potential H(+) leak mechanisms examined were UCPs (uncoupling proteins), allosteric activation of the ANT (adenine ...

BACKGROUND Double lumen dialysis catheters are routinely heparin or citrate 'locked' to maintain patency. Heparin lock-related bleeding episodes and antibiotic lock-related toxicity have been reported. The aim of this study is to quantify the amount of leak during 'lock' procedures and to compare leakage for different double lumen dialysis catheters. METHODS In an experimental, in vitro study...

BACKGROUND The effects of epidural needle design, angle, and bevel orientation on cerebrospinal fluid leak after puncture have not been reported. The impact of these factors on leak rate was examined using a dural sac model. Dural trauma was examined using scanning electron microscopy. METHODS Human cadaveric dura, mounted on a cylindrical model, was punctured with epidural needles using a mi...

In this paper we describe a simple scheme that uses feedback from underutilized high capacity links to allow a TCP connection to aggressively increase its sending rate. The feedback is in the form of a single bit in the packet header and is given per packet. The scheme uses aggregate information to provide feedback and does not require the routers to maintain per flow state. We show through sim...

Background: Colostomy is an artificial opening made in the large gut to divert faeces and flatus to the exterior OBJECTIVE: To compare the frequency of anastomotic leak in early versus delayed oral feeding after elective colostomy closure. MATERIAL AND METHODS: This randomized controlled study was conducted in Surgical department Hayatabad Medical Complex Peshawar from June 2012 to June 2014 af...