BACKGROUND AND OBJECTIVE Lead is known to have significant effects on bone metabolism and the immune system. This study tested the hypothesis that lead exposure affects periodontitis in adults. MATERIAL AND METHODS This study used the data from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-94). It analyzed data from 2500 men and 2399 women, 20-56 yr old, who rec...

Do socioeconomic status and family circumstances mediate the adverse effects of childhood lead poisoning? Or put more precisely, holding early-life lead exposure constant, do individuals from disadvantaged backgrounds exhibit more serious cognitive and behavioral deficits than individuals from more privileged backgrounds? Using a unique data set that links U.S. army recruits to early life circu...

OBJECTIVE Blood lead levels have declined among every age group in the United States, but urban minority residents remain at disproportionate risk for elevated lead levels. Our objective was to measure lead burden in young women of childbearing age in New York City. We also describe successful means of recruiting this population into a cohort study. MATERIAL AND METHODS Healthy women aged 18-...

the effects of including incoherent (bound-electron) and coherent (rayleigh) scattering in exposure buildup factor calculations for point isotropic gamma ray sources, penetrating a two-layer water-lead shield have been investigated in the gamma ray energy (e?) range of 40 kev to 3 mev. incoherent scattering decreases the values of these factors in both layers up to e? ~ 200 kev and the effect i...

In response to the growing body of scientific evidence about effects of exposure to low levels of lead, 1 the U.S. Centers for Disease Control and Prevention (CDC) has announced it is changing its guidelines for children's exposure to the toxic metal, reducing by half the blood lead level at which intervention is recommended. 2 According to CDC spokesman Jay Dempsey, the agency estimates the ch...

BACKGROUND Current evidence indicates that even low-level lead (Pb) exposure can have detrimental effects, especially in children. We tested the hypothesis that Pb exposure alters gene expression patterns in peripheral blood cells and that these changes reflect dose-specific alterations in the activity of particular pathways. METHODOLOGY/PRINCIPAL FINDING Using Affymetrix Mouse Genome 430 2.0...

Lead, which is widely used in industry, is a common element found in low concentrations in the Earth's crust. Implementations to reduce environmental lead concentrations have resulted in a considerable reduction of lead levels in the environment (air) and a sustained reduction in the blood lead levels of the average citizen. However, people are still being exposed to lead through a variety of r...

The objective of this pilot study was to investigate the contribution of environmental exposures to lead in the development of cytogenetic damage detected as the frequency of micronuclei (MN) in children. The other aim was to apply the MN assay in combination with fluorescence in situ hybridization (FISH) using a pan-centromeric chromosome probe to elucidate the formation mechanism of induced M...

OBJECTIVE To determine the status of environmental and occupational lead exposure in selected areas in Nairobi, Kenya. DESIGN Cross sectional study. SETTING Kariobangi North, Babadogo, Waithaka and Pumwani for assessment of environmental exposure to lead (Pb) and Ziwani Jua Kali works for assessment of occupational lead exposure. Olkalou in Nyandarua District was the covariate study area. ...

The authors sought to clarify in a cross-sectional study the possible associations between homeostatic regulators of calcium and occupational exposure to lead. Subjects were 146 industrial male employees, 56 with and 90 without occupational lead exposure. The main outcome measures were serum concentration of parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (calcitriol). The median values o...