نتایج جستجو برای: ldl c

تعداد نتایج: 1076959  

Journal: :Disease management : DM 2006
Patty Orr Adam Hobgood Sadie Coberley Patricia Roberts Gerrye Stegall Carter Coberley James Pope

Poor lipid control is a risk factor for cardiovascular diseases and diabetes complications. Frequently, however, patients with these diseases do not achieve blood lipid levels recommended by current standards of care. A retrospective study of 67,244 members eligible for disease management (DM) was initiated to evaluate the ability of interventions to promote improvement in low-density lipoprote...

2017
Wenduo Zhang Fusui Ji Xue Yu Xinyue Wang

Reducing low-density lipoprotein cholesterol (LDL-C) to target ≤1.81 mmol/L is a common therapeutic goal after acute coronary syndrome (ACS). This study aimed to examine the factors associated with reaching or not this LDL-C target after 1 year of optimal statin therapy postpercutaneous coronary intervention (PCI). This was a retrospective study of 633 consecutive prospectively enrolled patient...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1993
M Ohgushi K Kugiyama K Fukunaga T Murohara S Sugiyama E Miyamoto H Yasue

The mechanism(s) of inhibition of endothelium-dependent relaxation (EDR) by oxidized low-density lipoprotein (Ox-LDL) was examined in isolated porcine coronary arteries and rabbit aortas. Incubation with Ox-LDL but not native LDL caused the inhibition of thrombin- or acetylcholine-induced EDR, whereas A23187-induced EDR was preserved after incubation with Ox-LDL. Lysophosphatidylcholine (lysoPC...

2011
Ciriaco Carru Valeria Pasciu Salvatore Sotgia Angelo Zinellu Maria Cristina Nicoli Luca Deiana Bruna Tadolini Bastiano Sanna Bruno Masala Gianfranco Pintus

Antioxidants exert contrasting effect on low density lipoprotein (LDL) oxidation catalysed by metals, acting as pro-oxidants under select in vitro conditions. Through our study on the effect of coffee on LDL oxidation, we identified the parameters governing this phenomenon, contributing to the comprehension of its mechanism and discovering significant implications for correct alimentary recomme...

Journal: :Atherosclerosis 2014
Peter P Toth Michael Grabner Rajeshwari S Punekar Ralph A Quimbo Mark J Cziraky Terry A Jacobson

OBJECTIVES Previous research suggests that LDL particle number (LDL-P) may be a better tool than LDL cholesterol (LDL-C) to guide LDL-lowering therapy. Using real-world data, this study has two objectives: [1] to determine the incidence of CHD across LDL-P thresholds; and [2] to compare CHD/stroke events among patients achieving comparably low LDL-P or LDL-C levels. METHODS A claims analysis ...

Journal: :European heart journal 2017
Sophie J Bernelot Moens Annette E Neele Jeffrey Kroon Fleur M van der Valk Jan Van den Bossche Marten A Hoeksema Renate M Hoogeveen Johan G Schnitzler Marie T Baccara-Dinet Garen Manvelian Menno P J de Winther Erik S G Stroes

Aims Migration of monocytes into the arterial wall contributes to arterial inflammation and atherosclerosis progression. Since elevated low-density lipoprotein cholesterol (LDL-C) levels have been associated with activation of plasma monocytes, intensive LDL-C lowering may reverse these pro-inflammatory changes. Using proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (...

2016
Terry McCormack Ricardo Dent Mark Blagden

BACKGROUND Cardiovascular disease (CVD) is the leading cause of death in Europe and increased low-density lipoprotein cholesterol (LDL-C) is a major contributor to CVD risk. Extensive evidence from clinical studies of statins has demonstrated a linear relationship between LDL-C levels and CVD risk. It has been proposed that lower LDL-C levels than those currently recommended may provide additio...

2007
James O. Mudd

Recent clinical trials in patients with coronary artery disease (CAD) provide evidence that low-density lipoprotein cholesterol (LDL-C) levels should be lowered even further to prevent recurrent CAD. However, despite more aggressive interventions for lowering LDL-C levels, the majority of CAD events go undeterred, perhaps related to the fact that intervention was not started earlier in life or ...

Journal: :Journal of the American College of Cardiology 2007
David A Morrow

he pivotal role of low-density lipoprotein cholesterol LDL-C) in the pathogenesis of atherosclerosis and its schemic complications are well established. Epidemiologic tudies demonstrate a linear relationship between levels of DL-C and the prospective risk of cardiovascular events 1). In animal models, the administration of cholesterol ncreases levels of LDL-C and promotes the formation of esion...

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