Laser applications have been increasingly successful in many fields of medicine and may soon occupy an important position in medical therapeutics. In ophthalmology, where the unique non-scattering optical properties of the eye allow for tight focusing of laser light, the conditions of retinal detachment, retinal bleeding, and diabetic neovascularization are routinely treated with lasers. Nevert...

Introduction:  Laser  interstitial  thermotherapy  (LITT)  is  an  internal  ablation  therapy  method  consisting of a percutaneous or intraoperative insertion of laser fibers directly into the liver tumor with  maximum diameter of 5 cm. In this treatment method, there isn’t any general information about the  relationship  between  increasing  the  exposure  power,  coagulation  and  carboniza...

Experiments were performed to examine the feasibility of mass spectrometry (MS) depth profiling of animal tissue by ~75 fs, 800 nm laser pulses to expose underlying layers of tissue for subsequent MS analysis. Matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) was used to analyze phospholipids and proteins from both intact bovine eye lens tissue and tissue ablated by ultra...

introduction: with the rapid increase in use of lasers in medical treatments, it is important to understand the mechanisms of heat transfer in biological tissues in order to minimize damage to the tissues resulting from extra heat applied. the aim of this study is to investigate the temperature distribution in living biological tissues when laser irradiation is used in a treatment. methods:  in...

Transient thermal field in laser surface hardening treatment of medium carbon steel was analyzed by employing both three-dimensional analytical model and finite element model. In finite element model the laser beam was considered as a moving plane heat flux to establish the temperature rise distribution in the work-piece, while in analytical model laser beam was considered as an internal heat s...

The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO₂ laser that produces arrays of mi...

To enable an objective evaluation of photocoagulation, we characterize thermal tissue changes induced by laser irradiation with different laser parameters using optical coherence tomography (OCT). Spectral-domain OCT with a newly developed image processing method was used to monitor the thermal changes of ex vivo porcine retina. A sequence of OCT B-scans was obtained at the same retinal positio...

Selective tissue damage on the cellular level can be achieved by microbubble formation around laser-heated intracellular pigments. To acquire a more detailed understanding of the laser tissue interaction in the highly pigmented retinal pigment epithelium (RPE), we irradiate aqueous suspensions of absorbing microparticles by short pulsed laser irradiation (12 ns, 240 ns, and 1.8 micros). Porcine...

The success of any implant, dental or orthopaedic, is driven by the interaction of implant material with the surrounding tissue. In this context, the nature of the implant surface plays a direct role in determining the long term stability as physico-chemical properties of the surface affect cellular attachment, expression of proteins, and finally osseointegration. Thus to enhance the degree of ...

introduction: the unprotected eye is extremely sensitive to laser radiation and can be permanently damaged from direct or reflected beams. the area of the eye damaged by laser energy is dependent upon the wavelength of the incident laser beam, duration of exposure and tissue characteristics. this study aims to investigate the effect of intense green light from doubled frequency neodymium-doped ...