Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In ...

Retinoblastoma is the most common primary intraocular malignancy of infancy and childhood with an incidence of 1 in every 20,000 live births.1 During the 20th century, retinoblastoma was uniformly fatal. Early diagnosis and recent advances in the management of retinoblastoma particularly the use of chemo-therapy have improved the prognosis of this fatal disease. Although this neoplasm has one o...

PURPOSE Many treatment options to help relieve the symptoms of interstitial cystitis (IC) are available, but none are effective. Because no reports of transurethral ulcer resection with hydrodistention are available, we assessed the effects of such combined surgery for ulcerative IC. MATERIALS AND METHODS Between June 2006 and June 2011, 87 female patients with IC who underwent transurethral ...

Macromolecular transport through the interstitial space of a tissue occurs by convection and diffusion. The convective component of transport results from interstitial fluid flow. There have been no direct measurements of the magnitude or direction of interstitial fluid flow in tissues to date. Using fluorescence recovery after photobleaching, we have measured interstitial fluid velocities and ...

INTRODUCTION The efficacy of thermotherapy for the treatment of cutaneous leishmaniasis presents diverse results with low statistical power. OBJECTIVE To evaluate the efficacy of thermotherapy to treat cutaneous leishmaniasis. METHODS A meta-analysis of controlled clinical trials in 12 databases based on the implementation of a research protocol with inclusion and exclusion criteria and an ...

OBJECTIVE To evaluate tumor control and treatment complications following plaque radiotherapy combined with transpupillary thermotherapy for choroidal melanoma. DESIGN Prospective noncomparative interventional case series. INTERVENTION All patients received treatment for choroidal melanoma using plaque radiotherapy followed by 3 sessions of transpupillary thermotherapy provided at plaque re...

Ultrafast laser annealing of ion implanted Si has led to thermodynamically unexpected large {001} self-interstitial loops, and the failure of Ostwald ripening models for describing self-interstitial cluster growth. We have carried out molecular dynamics simulations in combination with focused experiments in order to demonstrate that at temperatures close to the melting point, self-interstitial ...