78 INTRODUCTION Gastroesophageal reflux disease (GERD) is implicated in many patients with chronic laryngitis. Ear, nose and throat (ENT) physicians often refer to this condition as laryngopharyngeal reflux (LPR) representing the retrograde movement of gastric contents, including acid, pepsin as well as bile acids, into the laryngopharynx (1,2). Typical LPR symptoms include dysphonia, globus ph...

BACKGROUND Laryngopharyngeal sensitivity (LPS) is important in preventing pulmonary aspiration and may be impaired by anaesthesia and stroke. It has been suggested that gastro-oesophageal reflux disease (GORD) may also impair LPS, although the underlying mechanism is unclear. The aim of this study was to compare LPS in patients with chronic cough and GORD with healthy subjects and to determine ...

Objective : To clarify the pathological mechanism of LPRD by studying the histological changes of the pharynxes and the larynxes in rats with chronic acid reflux esophagitis. Methods : An experimental rat model of chronic acid reflux esophagitis was surgically created. The pharynxes, larynxes, tracheas, lungs and esophagi of these rats were observed histologically every 2 weeks until 20 weeks a...

Background: Laryngopharyngeal sensitivity (LPS) is important in preventing pulmonary aspiration and may be impaired by anaesthesia and stroke. It has been suggested that gastro-oesophageal reflux disease (GORD) may also impair LPS, although the underlying mechanism is unclear. The aim of this study was to compare LPS in patients with chronic cough and GORD with healthy subjects and to determine...