BACKGROUND Two mutations in HFE, G845A (amino acid substitution C282Y) and C187G (H63D), are associated with hereditary hemochromatosis. We developed and validated a novel method, linked linear amplification (LLA), for detection of these two mutations. METHODS Two segments of HFE were amplified by a multiplex LLA reaction that generated biotinylated LLA products. Aliquots of the multiplex LLA...

Lukasiewicz logic arrays (LLAs) are analog VLSI circuits structured as trees of continuous-valued implications. First described in 1990, LLAs are now nding uses as applicationspeci c array processors for image processing, fuzzy inference, and robotic control. Yet an early question persists: Why do LLAs work? Intuitively, a small error should build up through successive implications of an arbitr...

a community of practice may shape and reshape the identity of members of the community through providing them with situated learning or learning environment. this study, therefore, is to clarify the salient learning-based features of the language teaching community of practice that might formulate the identity of language teachers. to this end, the study examined how learning situations in two ...

different factors determine language teachers’ degree of success in their teaching practices. among these factors, teachers’ own learning experience can play a pivotal role since it affects teachers’ attitudes toward aspects of the knowledge they are to teach. educators and researchers may have paid less attention to an indispensable component of teachers’ learning experience: learning strategi...

The present study examines whether the seductive-details effect is moderated by spatial ability and prior knowledge, which are two of the most relevant learner characteristics in multimedia learning. It is assumed that the seductive-details effect with an increase in extraneous cognitive load and a decrease in perceptual processing and learning success is only present for learners with low spat...

The poor patency rate following small-diameter vascular grafting remains a major hurdle for the widespread clinical application of artificial blood vessels to date. Our previous studies found that electrospun poly(L-lactide-co-epsilon-caprolactone) (P[LLA-CL]) nanofibers facilitated the attachment and growth of endothelial cells (EC), and heparin incorporated into P(LLA-CL) nanofibers was able ...

As language rhythm relies partly on general acoustic properties, such as intensity and duration, mastering two languages with distinct rhythmic properties (i.e., stress position) may enhance musical rhythm perception. We investigated whether competence in a second language (L2) with different rhythmic properties than a L1 affects musical rhythm aptitude. Turkish early (TELG) and late learners (...