نتایج جستجو برای: langendorff

تعداد نتایج: 1716  

Journal: :Cardiovascular research 2009
Catherine L Stables Michael J Curtis

AIMS We sought to generate a mouse Langendorff model of ischaemia-induced ventricular fibrillation (VF) that does not depend on triggers such as programmed electrical stimulation. METHODS AND RESULTS Hearts from male Tuck Ordinary mice were perfused with Krebs solution (modified to contain low-normal K(+), 3 mmol/L, and high Ca(2+), 2.4 mmol/L) containing different combinations of catecholami...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Richard H Kennedy Richard Owings Nawal Shekhawat Jacob Joseph

Previous studies have shown that chronic hyperhomocysteinemia is associated with an adverse cardiac remodeling and heart failure. This study, which utilized coronary-perfused hearts and superfused papillary muscle, was designed to determine whether homocysteine acts acutely to alter cardiac contractile function. Left ventricular developed pressure was used as a measure of systolic function in t...

Journal: :Circulation research 2016
Lija Swain Andrea Kesemeyer Stefanie Meyer-Roxlau Christiane Vettel Anke Zieseniss Annemarie Güntsch Aline Jatho Andreas Becker Maithily S Nanadikar Bruce Morgan Sven Dennerlein Ajay M Shah Ali El-Armouche Viacheslav O Nikolaev Dörthe M Katschinski

RATIONALE Changes in redox potentials of cardiac myocytes are linked to several cardiovascular diseases. Redox alterations are currently mostly described qualitatively using chemical sensors, which however do not allow quantifying redox potentials, lack specificity, and the possibility to analyze subcellular domains. Recent advances to quantitatively describe defined redox changes include the a...

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