Objective: To assess the inhibition activity of sesquiterpene lactones from Vernonia amygdalina Delile as a new anticancer potential on expression cancer therapeutic target-proteins, namely: epidermal growth factor receptor (EGFR), and vascular endothelial (VEGFR). Methods: The in silico screening, target‐based approach (docking) was performed by Prediction Activity Spectra for Substances (PASS...

Resorcylic acid lactones containing a cis-enone are susceptible to Michael addition reactions and are potent inhibitors of several protein kinases. A structural-bioinformatics analysis identified a conserved Cys residue in the ATP-binding site of the kinases reported to be inhibited by cis-enone resorcylic acid lactones but absent in those that are not. Mining of the kinome database revealed th...

Abstract A reliable LC-MS/MS method for the determination of five bioactive constituents (bilobalide, BLL; ginkgolide A, GLA; B, GLB; C, GLC; rutin) Ginkgo biloba leaf extracts (GBE) in rat plasma was established, fully validated and applied to an intragastric pharmacokinetic study a preparation GBE rat. Samples were extracted with ethyl acetate. C18 column selected as analytical this method. M...

The ethanolic and acetone extracts of the whole plant of Elephantopus scaber were found to contain ethyl hexadecanoate, ethyl-9,12-octadecadienoate, ethyl-(Z)9-octadecenoate, ethyl octadecanoate, lupeol, stigmasterol, stigmasterol glucoside, deoxyelephantopin (1) and two new germacranolide sesquiterpene lactones named 17,19-dihydrodeoxyelephantopin (2) and iso-17,19-dihydrodeoxyelephantopin (3)...

Phytochemical study on the ethanol extract of the aerial parts of Carpesium abrotanoides led to the isolation of two new sesquiterpene lactones, carabrolactone A (1) and carabrolactone B (2). Their structures were elucidated on the basis of extensive spectroscopic analysis.

Reduction of the natural sesquiterpene lactones furanoheliangolides with Stryker's reagent is an effective process for producing eremantholides through a biomimetic pathway. Other reduction products are also formed. Oxygenated functions at C-15 of the furanoheliangolide produce an increase in the velocities of the reactions and reduce the chemoselectivity of the reagent.

Ginkgo biloba leaf is the leaf of Ginkgo biloba L. in the genus Ginkgo of family Ginkgoaceae. It has the actions of benefiting heart, astringing lung, resolving dampness and stopping diarrhea, which can be used in the treatment of chest distress and pain, palpitation, phlegm panting and cough, diarrhea, dysentery, leucorrhea and other symptoms. Main active constituents of Ginkgo biloba leaves a...