Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism occurring in most cell types. However, this housekeeping gene is expressed at very high levels in a number of mammalian tissues including the lactating mammary epithelium, suggesting additional roles for XOR in these tissues. Mice with targeted disruption of XOR were generated to assess these potential additional rol...

The transition period for dairy cows is generally defined as the time period from three weeks prior to parturition through three weeks after parturition. It is now recognized that defining and meeting the nutritional requirements of the transition dairy cow can greatly impact animal health, production in the ensuing lactation, overall longevity, and animal well-being (NRC, 2001). Nutrition and ...

Serotonin regulates numerous processes in the mammary gland. Our objective was to discover novel genes, pathways and functions which serotonin modulates during lactation. The rate limiting enzyme in the synthesis of non-neuronal serotonin is tryptophan-hydroxylase (TPH1). Therefore, we used TPH1 deficient dams (KO; serotonin deficient, n = 4) and compared them to wild-type (WT; n = 4) and rescu...

The authors report a case-control study of breast cancer based on an analysis of data collected by interview between the years 1957-1965 from women residing in the communities of Buffalo and Kenmore, New York. Prior reproductive factors, including a detailed lactation history, were examined for 453 white females with breast cancer and 1,365 white females without breast cancer who were selected ...

There are many potential applications of transgenic methodologies for developing new and improved strains of livestock. One practical application of transgenic technology in pig production is to improve milk production or composition. The first week after parturition is the period of greatest loss for pig producers, with highest morbidity and mortality attributed to malnutrition and scours. Des...

The physiology of human lactation is described with secretions on mammary gland anatomy and development, the mechanisms of milk secretion and ejection, and the temporal sequence of events during the transition from pregnancy to lactation (lactogenesis). Finally, interactions between lactation and maternal metabolism are briefly described and the interaction of lactation with fertility discussed.

osteoporosis is considered as an important public health problem especially in postmenopausal women. there are some hypotheses support the contributory effect of pregnancy and lactation on osteoporosis later in life. high calcium demand during pregnancy and lactation and low estrogenic state support those hypotheses. numerous studies have investigated on the issue but there is no consensus abou...

This investigation evaluated mammary cell loss and replacement during lactation and the impact of administration of bST on these processes. During lactation, a gradual decrease in number of mammary epithelial cells within the mammary glands occurs and largely accounts for the decline in milk production with advancing lactation. This decrease is not appreciably impacted by the loss of viable epi...

Several functions were used to model fixed and random part of the lactation curve in Iranian primiparous Holstein cows using random regression analysis. Legendre polynomials of orders three and four as well as parametric lactation curve for the random part of the first lactation milk production were compared to find the best model. The models differed in fixed regression lactation curve part an...

DNA methylation (DNAm), a major element of epigenetics, plays critical roles in individual development. Reduced representation bisulfite sequencing (RRBS) is an effective and economical method for analyzing the DNA methylation of a single base. The aims of this study were to determine the DNAm profiles of the methylation contexts (CGs and non-CGs) of lactation and dry periods of goat mammary gl...