Antimicrobial susceptibilities of 23 strains of Desulfovibrio spp. were tested by Etest. Generally, Desulfovibrio spp. were highly susceptible to sulbactam-ampicillin, meropenem, clindamycin, metronidazole, and chloramphenicol: MIC(90)s of 6, 4, 0.19, 0.25, and 8 microg/ml, respectively. In addition, these strains generally showed high MICs to piperacillin and piperacillin-tazobactam. Desulfovi...

Azetidine-2,3-diones (alpha-oxo-beta-lactams) and bromonitromethane undergo coupling in aqueous media in the presence of catalytic amounts of sodium azide. The stereoselectivity of the process was generally good, proceeding with reasonable anti : syn ratios under substrate control. On this basis, a simple and fast protocol for the synthesis of the potentially bioactive 3-substituted 3-hydroxy-b...

A new chemoselective reductive nitro-Mannich cyclization reaction sequence of nitroalkyl-tethered lactams has been developed. Relying on the rapid and chemoselective iridium(I)-catalyzed reduction of lactams to the corresponding enamine, subsequent nitro-Mannich cyclization of tethered nitroalkyl functionality provides direct access to important alkaloid natural-product-like structures in yield...

The conjugate addition reaction has been a useful tool in the formation of carbon-carbon bonds. The utility of this reaction has been demonstrated in the synthesis of many natural products, materials, and pharmacological agents. In the last three decades, there has been a significant increase in the development of asymmetric variants of this reaction. Unfortunately, conjugate addition reactions...

The rising demand for chiral raw materials, intermediates, and active ingredients in pharmaceuticals, agrochemicals, food additives, and fragrances provides the impetus for rapid developments in chiral technology.[1] It remains a huge challenge for organic chemists to develop highly enantioselective reactions for the preparation of enantiomerically pure compounds in a cost-effective manner. Lac...

The mixed anhydrides with N-acyl carbamic acid (IV) were prepared by the reaction of carboxylic acids (Ill) with N-chlorocarbonyl lactams (Ila) or sec. amides (lib). Decarboxylation of IV yielded N-acyl lactams (VI), while symmetrical anhydrides (VII) were obtained by the side reaction of IV with carboxylic acids (III). Aminolysis of IV yielded carboxylic acid amides (IX) in high yield and puri...

Objective. The purpose of the research was to study features course acute purulent lymphadenites and adenophlegmons maxillofacial region in children, describe species composition pathogens, determine their sensitivity antibiotics various groups.
 Materials methods. medical histories 147 patients were analyzed; microbiological studies carried out (microscopic examination clinical specimens ...