hDM2 is recognized in vivo by a short alpha-helix within the p53 trans-activation domain (p53AD). Disruption of the p53.hDM2 interaction is an important goal for cancer therapy. A functional epitope comprised of three residues on one face of the p53AD helix (F19, W23, and L26) contributes heavily to the binding free energy. We hypothesized that the p53AD functional epitope would be recapitulate...

When parallel applications are run in large-scale distributed environments, such as grids, peer-to-peer (P2P) systems, and clouds, the set of resources used can change dynamically as machines crash, reservations end, and new resources become available. It is vital for applications to respond to these changes. Therefore, it is necessary to keep track of the available resources—a problem which is...

The contribution of specific HLA Class II alleles in type 1 diabetes is determined by polymorphic amino acid epitopes that direct antigen binding therefore, along with conventional allele frequency analysis, epitope analysis can provide important insights into disease susceptibility. We analyzed the highly heterogeneous Cypriot population for the HLA class II loci of T1DM patients and controls ...

One hundred and three cases of Non-Hodgkin's lymphoma were evaluated immunohistochemically using a panel of monoclonal antibodies which includes leucocyte common antigen (LCA), CD45R (Pan-B marker), L-26 (CD 20-Pan-B marker) and UCHL-1 (Pan-T marker). Of the total 63 cases (61.17%) showed a B-cell phenotype while 40 (38.83%) were of T-cell origin. Most B-cell neoplasms belonged to intermediate ...

1930 yılından günümüze uzanan aerojeller; Guinness rekorlar kitabına giren en hafif ve katı malzeme olarak seçilmiştir. Yüksek ısıl absorbsiyon özelliği, çok iyi yalıtkanlık kabiliyeti, mezo gözenek yapısı mukavemetinin yüzey alanının yüksek olması gibi üstünlüklerinin birçok malzemeye alternatif kullanım avantajı sektörde olanağı sunmaktadır. Bu çalışmada, sol-jel tekniği kullanılarak saflıkta...

Although multiple interactions of seminiferous tubules and the interstitial testicular tissue are known, correlation of cytokeratin 18 expressing Sertoli cells with interstitial changes has still not yet been reported. Considering this fact, we focused our investigation on changes of the adjacent interstitial tissue. A total sample of 51 testicular biopsies (from infertile patients) showing mix...