Genetic engineering of plants has turned out to be an attractive approach produce various secondary metabolites. Here, we attempted kynurenine, a health-promoting metabolite, in Nicotiana tabacum (tobacco) transformed by Agrobacterium tumefaciens with the gene, coding for human indoleamine 2,3-dioxygenase 1 (IDO1), enzyme responsible kynurenine production because tryptophan degradation. The pre...

(2016). Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: Explore Bristol Research is a digital archive and the intention is that deposited content shou...

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The cover image is based on the Research Article Electrochemical Detection of Tryptophan Metabolites via Kynurenine Pathway by Using Nanocarbon Films Dai Kato et al., DOI: 10.1002/elan.202100241, which part Special Collection Electroanalysis Based Carbon Nanomaterials.

Le tryptophane (Trp) et ses métabolites modulent la réponse inflammatoire sont des marqueurs indirects de dysbiose intestinale. Nous avons souhaité étudier leur rôle potentiel dans l’arthrose digitale (AD). À partir 418 patients atteints d’AD cohorte DIGICOD, 16 sériques du Trp appartenant aux 3 voies Kynurénine-IDO, l’indole ou sérotonine ont été quantifiés par chromatographie liquide à haute ...

It has been shown previously that kynurenine hydrolase (L-kynurenine hydrolase, EC 3.7.1.3) is inhibited by the hydrazide Benserazide {R,, 4-4602, DL-serine 2-[(2,3,4trihydroxyphenyl)methyl] hydrazide), a compound that is used clinically in the treatment of Parkinson’s disease (Bender et al., 1977). Benserazide is a potent inhibitor of aromatic amino acid decarboxylase (L-aromatic amino acid ca...

OPen ACCess Full open access to this and thousands of other papers at The 13th international conference of the International Society for Tryptophan Research (ISTRY) has been held in Sydney, 7th to 9th of November 2012. It was a really successful meeting with high quality speakers and presentations. ISTRY 2013 has attracted attendees from 14 different countries—Australia, A satellite meeting org...