Human papillomavirus (HPV) infection of the mouth and oropharynx can be acquired by a variety of sexual and social forms of transmission. HPV-16 genotype is present in many oral and oropharyngeal squamous cell carcinomata. It has an essential aetiologic role in the development of oropharyngeal squamous cell carcinoma in a subset of subjects who are typically younger, are more engaged with high-...

INTRODUCTION Squamous cell carcinoma is one of the most common malignant tumors of the skin and oral mucosa. However, squamous cell carcinoma involving near total upper and lower lip and oral commissure is rarely seen in the English literature. Simultaneous reconstruction of the upper and lower lips has been inconclusive and presents a challenge to the surgeon. We report such a case and outline...

Objective: Oral Squamous Cell Carcinoma (OSCC), which is the sixth most prevalent type of cancer across globe caused by cigarette smoking, smokeless tobacco use, excessive and extreme alcohol oral trauma, HPV (Human Papilloma Virus) infection as well genetic mutations. AIF-1(Allograft Inflammatory Factor) has been identified an inflammatory response modulator, its increased expression linked to...

the role of oxygen free radicals in the initiation, promotion and progression of carcinogenesis and the protective role of anti-oxidant defenses has been the subject of much speculation in the recent past with conflicting reports in the literature. in recent years, increasing experimental and clinical data have provided compelling evidence for the involvement of oxidative stress in a large numb...

High risk forms of the human papilloma virus (HPV) are generally accepted as necessary causative agents for cervical cancer. Recently, a possible relation between HPV and oral squamous cell carcinoma (OSCC) has also been noticed. The present study was conducted to investigate the prevalence of HPV infection in OSCCs in Wuhan city. DNA samples were collected from fresh tissues in 200 patients wi...

Background/Purpose: Oral Squamous cell carcinoma is sixth most common cancer with considerable morbidity and mortality. The microRNAs (miRNAs) are set of short RNAs involved in regulating the expression protein coding genes. They up or down-regulated carcinogenesis oral cancer. miRNA-31 (miR-31) increased Objective: To evaluate compare plasma squamous control subjects. Materials Methods: Case s...

INTRODUCTION Oral verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma which possesses specific clinical, morphologic and cytokinetic features that differ from other types of oral cancers and hence diagnosis requires immense experience in histopathology. Hence it is certainly important to distinguish such a lesion from other oral tumors as treatment strategies va...

Among oral lesions, we encounter a series of malignant epithelial lesions that go through clinical and histopathologic processes in order to be diagnosed. Identifying these processes along with the etiology knowledge of these lesions is very important in prevention and early treatments. Dysplasia is the step preceding the formation of squamous cell carcinoma in lesions which have the potential ...

Accurate identification of the microscopic risk factors of oral and oropharyngeal (OP) squamous cell carcinomas (SCC) and their morphologic variants is of at most importance, as these generally determine treatment modalities, prognosis and overall patient outcome. The great majority of oral and oropharyngeal squamous cell carcinomas are microscopically described as kerartinizing squamous cell c...

Researchers have proposed that tumor development is based exclusively on the activity of cancer stem cells (CSCs), the so-called CSC hypothesis. This new model of carcinogenesis may offer insights into the high mortality of oral cancer, the poor response to treatment, and the elevated risk of multiple tumors in patients with oral squamous cell carcinoma (OSCC). Greater knowledge is needed of th...