A series of 3,5-bis(hetero)arylethenyl-substituted BODIPY derivatives have been prepared by Knoevenagel-type condensation alkyl-substituted with the corresponding aldehydes. 2-Pyrrolylethenyl-substituted feature near-IR emission (?em > 700 nm) a high fluorescence quantum yield. Both maxima and yields are relatively insensitive to solvent polarity, contrary near-IR-emitting 4-(N,N-dimethylaminop...

A new and non-infringing efficient one-pot process for the preparation of catechol-O- methyltransferase (COMT) enzyme inhibitors, entacapone 1 under mild condition, initially reaction 3-methoxy-4-hydroxy-5-nitro-benzaldehyde 5 with 2-cyano acetic acid 13 in presence organic base benzyl Trimethyl ammonium hydroxide, i.e. Triton-B which undergo Knoevenagel condensation to get intermediate 22 is t...

The escalating demand for the cost-effective synthesis of valuable fine chemicals has fueled search sustainable heterogeneous catalysts. Among these catalytic reactions, Knoevenagel condensation emerged as a very demanding reaction due to its involvement in new C–C bond formation. Porous metal phosphates have attracted significant attention catalysis their unique surface properties. In this stu...

Abstract Nitrogen‐rich carbon nitrides are desired materials for base‐catalysed transformations; however, their synthesis is challenging due to the volatile nature of N at high temperatures. Herein, we report on temperature‐controlled ordered N‐rich mesoporous (MCNs) via pyrolysis aminoguanidine by using SBA‐15 as a hard template. The properties and nitrogen content were tuned varying carboniza...

The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction of the O-alkylated ketone 13 afforded good yield of precusor alcohol 5. Final coupling of alcohol...

A group of novel heterocyclic arylsulfonamide derivatives were synthesized by three steps process using the organic and inorganic catalyst in less solvent at ambient temperature. One out three-steps process, one-pot multiple component reaction reusable catalyst. These compounds reactions proceed through Knoevenagel condensation accompanied Michael addition to obtaining suspicious products. The ...