Meclizine HCl is a poorly water-soluble drug having a very slow-onset of action. The effect of 2-hydroxypropyl-β-cyclodextrins and β-cyclodextrins on its aqueous solubility and dissolution rate was investigated. The phase solubility profile indicated that the solubility of Meclizine HCl was significantly increased in the presence of both 2-hydroxypropyl-β-cyclodextrin and β- cyclodextrin; an ex...

Dry whey enriched with magnesium and manganese (DW) that contains protein in the amount of 13 %, a concentrate (WPC) content 65 have been chosen as functional bases production complex baking improvers targeted effect. When developing composition improver, rational dosage DW is 2 % by weight flour, WPC – 3 flour. Adding during kneading wheat flour dough predetermines decrease its gluten content,...

We give a new proof that all external rays of the Mandelbrot set at rational angles land, and of the relation between the external angle of such a ray and the dynamics at the landing point. Our proof is different from the original one, given by Douady and Hubbard and refined by Lavaurs, in several ways: it replaces analytic arguments by combinatorial ones; it does not use complex analytic depen...