BACKGROUND Tendinopathy is very common in the general population. There are increasing numbers of clinical studies referring to platelet-rich plasma (PRP) and platelet-poor plasma (PPP) as treatments for tendinopathy. PURPOSE To perform a meta-analysis of the outcomes of the PRP groups by preparation method and injection technique in tendinopathy. To determine the clinical effectiveness of th...

Abstrak: Pembelajaran IPA di SMP Unismuh Makassar masih bersifat konvensional, yaitu pembelajaran didominasi oleh kegiatan ceramah dan diskusi. Keterbatasan Komponen Instrumen Terpadu (KIT) Praktikum kurangnya Sumber Daya Manusia (SDM) yang mampu mendesain praktikum merupakan permasalahan mitra. Kegiatan Pengabdian ini bertujuan untuk meningkatkan kemampuan kompetensi pengelolaan laboratorium G...

In the present study, modified indigenous ELISA kit (kit 1) was compared with indigenous ELISA kit (kit 2) and commercial ELISA kit (kit 3) for its sensitivity and specificity with respect to faecal culture for diagnosis of Johne's disease in goats and sheep under natural conditions. Of the 64 positive animals, serum of 42.1, 48.4 and 18.7% animals yielded positive infection in kit 1, 2 and 3, ...

Activation of the KIT receptor tyrosine kinase contributes to the pathogenesis of several human diseases, but the mechanisms regulating KIT signaling have not been fully characterized. Here, we show that stem cell factor (SCF), the ligand for KIT, induces the interaction between KIT and Cbl proteins and their mutual degradation. Upon SCF stimulation, KIT binds to and induces the phosphorylation...

Hematopoietic stem cells (HSCs) are heterogeneous with respect to their self-renewal, lineage, and reconstitution potentials. Although c-Kit is required for HSC function, gain and loss-of-function c-Kit mutants suggest that even small changes in c-Kit signaling profoundly affect HSC function. Herein, we demonstrate that even the most rigorously defined HSCs can be separated into functionally di...

We screened for natural mutations in Crl:CF1 closed colony mice using an ordinary backcrossing system. Five of 30 CF1 males carried novel genes that caused white spots on colored coats. Their backcross progenies showed a white spot phenotype. The white spot gene was mapped to approximately 39 cM on chromosome 5, where the Kit gene is known to reside. Allelism testing between this spot gene and ...

Objective: Via the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) 30-50 kDa is generated, lacking extracellular and transmembrane domains. Moreover, over-expression tr-KIT, stronger activator than c-KIT, appears to be specific prostate cancer (PCa). Also, Imatinib, tyrosine kinase inhibitor, blocks activity full-length but has no effect on tr-KIT in PCa. Tr-KIT its own nucle...