نتایج جستجو برای: kidney tumours
تعداد نتایج: 250175 فیلتر نتایج به سال:
OBJECTIVES Stereotactic body radiation therapy (SBRT) is a new therapeutic paradigm that uses a very large dose per fraction treatments (ablative hypofractionation). We investigated the use of ablative hypofractionation in treating human renal cell carcinoma using a nude mouse model. METHODS Nude mice were injected subcutaneously with A498 human renal carcinoma cells. Tumour-bearing animals w...
Electrolyte alterations and extra-renal disorders are quite frequent in patients undergoing haemodialysis or peritoneal dialysis. The native kidneys may be the site of important pathologies in patients undergoing dialysis, especially in the form of acquired renal cystic disease with frequent malignant transformation. Renal neoplasms represents an important complication of haemodialysis-associat...
Wilms tumour is the most common childhood kidney cancer. Here we report the whole-exome sequencing of 44 Wilms tumours, identifying missense mutations in the microRNA (miRNA)-processing enzymes DROSHA and DICER1, and novel mutations in MYCN, SMARCA4 and ARID1A. Examination of tumour miRNA expression, in vitro processing assays and genomic editing in human cells demonstrates that DICER1 and DROS...
W ilms tumour (WT) is the most common malignant neoplasm of the kidney in childhood and accounts for approximately 8% of all childhood solid tumours. 2 Fetal rhabdomyomatous nephroblastoma (FRN) is a histological variant of WT characterised by a predominance of rhabdomyogenic components. Clinically, WT of the FRN type presents as a huge mass in younger patients and about 30% of them have bilate...
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of kidney cancer and is often characterized by mutations or deletions of the Von Hippel Lindau (VHL) tumour suppressor gene. Aurora gene family members are implicated in proper mitotic progression and spindle checkpoint function and play a crucial role in cancer progression. In the present study, we assessed the exp...
Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes of 31 pRCCs, and in four tumours, multi-region sequencing is undertaken. We identify BAP1, SETD2, ARID2 and Nrf2 pathway genes (KEAP1, NHE2L2 and CUL3) as probable drivers, together with at le...
the rectum villous tumour is an uncommon pathology in paediatrics, it represent 1% of all the children's malign tumours. an eleven-year-old girl present a rectal adenocarcinoma developed from a villous tumour. the aim of this study is to assess , an overview of litterature, the frequency of rectum villous tumours; to specify the value of the clinical examination , of the radiologic finding in t...
Severe acute respiratory syndrome (SARS) coronavirus?2 (SARS?CoV?2), the causative viral agent for ongoing COVID?19 pandemic, enters its host cells primarily via binding of SARS?CoV?2 spike (S) proteins to angiotensin?converting enzyme 2 (ACE2). A number other cell entry mediators have also been identified, including neuropilin?1 (NRP1) and transmembrane protease serine (TMPRSS2). More recently...
Analysis of mortality from malignant tumours in Switzerland over the period 1921-1978 shows a considerable rise in the death rates from lung cancer and from malignant melanoma, and also an increase in death rates from cancers of pancreas, kidney, bladder, prostate, ovary and breast. Mortality from cancer of stomach (in the past the biggest killer of all cancers) has, on the other hand, drastica...
organs. The volume consists of twenty-five lectures, three on urethral stricture, one on the urethroscope, catheterisation of the ureters, etc. Then follows two lectures on enlargement of the prostate and its symptoms and complications. Chapter VII gives a lucid description of the author's well-known operation and the next four chapters deal with the scope and limits of this operation and the o...
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