Kidney disease has emerged as a risk factor for mortality in heart failure populations. The objective of this study was to determine the impact of different stages of kidney dysfunction (defined using the Kidney Disease Outcomes Quality Initiative [K/DOQI] classification system) and changes in kidney function on mortality in a cohort of patients with heart failure. A retrospective analysis was ...

BACKGROUND Proenkephalin (pro-ENK), a stable and reliable surrogate marker for unstable enkephalins, was found to be associated with acute kidney injury and chronic renal failure in previous studies. We aimed to investigate whether pro-ENK is linked to chronic kidney injury and poor long-term outcome in renal transplant recipients (RTR). METHODS We included 664 stable RTR and 95 healthy kidne...

Multicystic dysplastic kidney (MCDK) is the most common cystic kidney disease in children. Renal abnormalities occur in the contralateral kidney in 20-57% of cases. The prognosis of MCDK depends primarily on the status of the opposite kidney. We describe a case of unilateral MCDK and contralateral hypoplasia presenting with renal failure during the neonatal period. Abdominal ultrasound showed a...

BACKGROUND Patients with chronic kidney disease (CKD) are at risk to progress to kidney failure. We previously developed the Kidney Failure Risk Equation (KFRE) to predict progression to kidney failure in patients referred to nephrologists. OBJECTIVE The objective of this study was to determine the ability of the KFRE to discriminate which patients will progress to kidney failure in an unrefe...

Congestive heart failure, chronic kidney insufficiency and anemia are often present in the same patient. We have coined this triad the cardio-renal anemia syndrome. We suggest that congestive heart failure can often cause chronic renal failure, with both diseases producing anemia. The anemia exacerbates the chronic heart failure, which then worsens the chronic renal failure, causing further ane...

Uremic stomatitis is a rare disease that affects the oral mucosa, caused by acute or chronic advanced kidney failure. Of poorly known etiopathogenesis, the condition has been associated with high levels of salivary ammonia. Four clinical manifestations have been described: ulcerative, non-ulcerous pseudo membranous, hyperkeratotic, and hemorrhagic uremic stomatitis. Since uremic stomatitis has ...

To study the role of smoking in renal damage, we measured gender-specific effects, dose-response relationships, and whether cessation reduced the risk of smoking on future kidney failure. During a median follow-up of 10.3 years, 124 of 65,589 participants of the HUNT II study, a Norwegian population, progressed to stage 5 chronic kidney disease. Former- and current-smokers less than 70 years of...

congenital hepatic fibrosis (chf) is a rare disease that affects both the liver and kidneys.  congenital hepatic fibrosis (chf) is an autosomal recessive inherited malformation defined pathologically by a variable degree of periportal fibrosis and irregularly shaped proliferating bile ducts. affected individuals also have impaired renal function, usually caused, in children and teenagers, by an...

Biomarkers are useful tools for diagnosis and risk assessment of acute kidney injury and acute heart failure, particularly in ICU patients. Most biomarkers are produced or cleared by the kidney, so the presence of chronic kidney disease may affect their clinical reliability, particularly if the putative diagnosis of acute kidney injury or acute heart failure is based on a single measurement/sin...