نتایج جستجو برای: kidney damage
تعداد نتایج: 435635 فیلتر نتایج به سال:
Ischemia/reperfusion (I/R) injury in the kidney is a major cause of acute kidney injury (AKI) in humans and is associated with significantly high mortality. To identify genes that modulate kidney injury and repair, we conducted genome-wide expression analysis in the rat kidneys after I/R and found that the mRNA levels of fibrinogen (Fg)α, Fgβ, and Fgγ chains significantly increase in the kidney...
oxygen-derived free radical* (ofr) involvement in ischacmia-rcpcrfusion (ir) injury was investigated in a rat isolated kidney model, using 20 minutes iscliaemia followed by 15 or 60 minutes reperfusion. two antioxidants, the xanthine oxidase inhibitor allopurinol and the hydroxyl radical scavenger dimcthylthiourca (dmtu), were uscit to try and prevent ofr-relatcd damage. renal function was esti...
INTRODUCTION Kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of ...
Hypertensive patients exhibit elevated cancer incidence, especially of cancers of the kidney. Elevated levels of ANG II, the active peptide of the renin-angiotensin system, regulating blood pressure and cardiovascular homeostasis, are known to cause hypertension and kidney diseases. There is evidence that ANG II is an activator of NAD(P)H oxidase, leading to the formation of free radicals, whic...
Summary Monoclonal gammopathy of renal significance (MGRS) encompasses a group kidney disorders in which monoclonal immunoglobulin secreted by B cell or plasma clone causes damage, without meeting hematological criteria for malignancy. The underlying disorder patients with MGRS is generally consistent undetermined (MGUS). Because the wide spectrum MGRS-associated diseases, defined through locat...
background nephrotoxicity and hepatotoxicity are side effects of cisplatin (cp) therapy. objectives we investigated the role of gender in cp-induced nephrotoxicity and hepatotoxicity. materials and methods low dose of cp (1 mg/kg/day; ip) was administered daily to male and female wistar rats for 15 consecutive days. serum creatinine (cr), blood urea nitrogen (bun), malondialdehyde (mda), nitric...
BACKGROUND Urine protein loss is common in dogs with chronic kidney disease (CKD). HYPOTHESIS/OBJECTIVES To evaluate new biomarkers of glomerular and tubulointerstitial (TI) damage compared with histology and as survival indicators in dogs with naturally occurring, proteinuric CKD. ANIMALS One hunderd and eighty dogs with naturally occurring kidney disease. METHODS Retrospective study usi...
Kidney may undertake normal function immediately after transplantation or even several or over a dozen days delay. Absence of normal renal transplant function may lead to acute kidney injury (AKI), nephrotic syndrome (NS) and chronic kidney disease (CKD). Acute kidney injury (AKI) is characterized functionally by a rapid decline in the glomerular filtration rate (GFR), and biochemically by the ...
Objective(s): Diazinon (DZ) is an organophosphate pesticide that induces oxidative damage in different organs. The aim of this study was to compare the effectiveness of nanomicelles containing curcuminoids (NCUR) and natural curcumin (CUR) in attenuating the oxidative damage induced by DZ in male rats. Materials and Methods: After a single intraperitoneal (IP) injection of DZ (100 mg/kg), the r...
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