For ethical, regulatory, and economic reasons, in vitro human digestion models are increasingly used as an alternative to in vivo assays. This study aims to present the new Engineered Stomach and small INtestine (ESIN) model and its validation for pharmaceutical applications. This dynamic computer-controlled system reproduces, according to in vivo data, the complex physiology of the human stoma...

OBJECTIVE To investigate the effects of pain treatment on sleep in nursing home (NH) patients with dementia and depression. METHODS A multicenter, 2-armed, double-blinded, placebo-controlled, randomized clinical trial conducted between August 2014 and September 2016. One hundred six long-term patients from 47 NHs in Norway with dementia and depression according to the Mini-Mental State Examin...

BMJ VOLUME 325 28 SEPTEMBER 2002 bmj.com Staff at the Food and Drug Administration’s Office of Drug Safety wanted the United States to consider following the United Kingdom’s policy of reducing the public’s ease of access to paracetamol to try to reduce the number of deaths from overdose, a concern in both these countries. But the office’s views never reached the FDA’s nonprescription drugs adv...

pain in icu patients should be managed effectively and safely. fentanyl and paracetamol are used frequently in icu. however experience using iv paracetamol in the setting of critically ill patients is limited. we evaluated the analgesic effect and adverse reactions of intravenous paracetamol compared to fentanyl in icu patients with mild to moderate pain. forty patients in a general icu were ra...

With the growing pace of tablets use and the large focus it is attracting especially in higher education, this paper looks at an important aspect of tablets; their carbon footprint. Studies have suggested that tablets have positive impact on the environment; especially since tablets use less energy than laptops or desktops. Recent manufacturers’ reports on the carbon footprint of tablets have r...

Background: Fever is a very common adaptive immune response in acute respiratory tract disorders during infancy. Antipyretic / analgesic drugs such as paracetamol (acetaminophen) are widely used to improve the comfort of child. Objective: To determine efficacy symptomatic relief upper infections children aged 2 5 years. Study Design: Descriptive case series Setting: Department Pediatrics, Ayub ...