A supramolecular platform based on self-assembled monolayers (SAMs) has been implemented in a microfluidic device. The system has been applied for the sensing of two different analyte types: biologically relevant phosphate anions and aromatic carboxylic acids, which are important for anthrax detection. A Eu(III)-EDTA complex was bound to β-cyclodextrin monolayers via orthogonal supramolecular h...

A new series of oxovanadium (IV) tetraazamacrocyclic complexes type [VO(mac)]SO4, have been synthesized via in situ reaction 1,8-diaminonaphthalene and substituted β-diketones (1-phenyl-3-(phenyl/4-chlorophenyl/4-hydroxyphenyl/4- methoxyphenyl/4-nitrophenyl)-diketone) the presence oxovanadium(IV) sulphate methanol. Attempts to synthesize corresponding metal free macrocyclic ligands did not prov...

Genetically encoded macrocyclic peptide libraries with unnatural pharmacophores are valuable sources for the discovery of ligands many targets interest. Traditionally, generation such employs “early stage” incorporation building blocks into chemically or translationally produced macrocycles. Here, we describe a divergent late-stage approach to starting from readily available material: genetical...