Fasciolosis is the most common animal disease and one of the important causes of deterioration in livestock productivity in Nepal. It is widespread throughout the country affecting all species of ruminants. Despite increased awareness of the disease and massive increase in the use of anthelmintics, there appears to be no impact on the prevalence of the disease in the last two decades. Failure t...

Molluscicidal activity of Solanum nigrum var. villosum (morelle velue) extracts and their fractions were tested against the mollusca gastropoda Galba truncatula intermediate host of Fasciola hepatica. The results indicated that the hydro-methanol (MeOH-H2O) immature fruit extract possess the highest molluscicidal activity (LC50 = 3.96 mg/L) against Galba truncatula compared with other tested co...

Fasciolosis is a food borne zoonosis, caused by the digenetic trematode Fasciola. Freshwater lymnaeid snails are the intermediate host of the trematodes. Chlorophyllin, a semi-synthetic derivative of chlorophyll and its formulations obtained from freeze dried cow urine (FCU) had their toxicity tested against redia and cercaria larvae of F. gigantica. The larvicidal activity of chlorophyllin and...

Liver fluke or Fasciola hepatica is a common parasite of livestock. A liver fluke infection causes ill health, as well as a reduction in growth rates and reproductive performance in affected livestock. Over recent years it has been acknowledged that the presence of liver fluke in the UK has increased and that the periods of risk for infections have become longer, as well as more difficult to pr...

Major advances have been made in identifying potential vaccine molecules for the control of fasciolosis in livestock but we have yet to reach the level of efficacy required for commercialisation. The pathogenesis of fasciolosis is associated with liver damage that is inflicted by migrating and feeding immature flukes as well as host inflammatory immune responses to parasite-secreted molecules a...