BACKGROUND Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation. OBJECTIVE This literature review aims to analyse advan...

UNLABELLED BACKGROUND Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be due to an up-regulation of inflammatory mediators in the airway. It is now well recognized that chronic inflammation as well as airway hyper-...

BACKGROUND Avoidant personality disorder is characterized by pervasive anxiety, fear of criticism, disapproval, and rejection, particularly in anticipation of exposure to social situations. An important but underexplored question concerns whether anxiety in avoidant patients is associated with an impaired ability to engage emotion regulatory strategies in anticipation of and during appraisal of...

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the neuronal structures and cells affected, a unifying theory that could explain the manifold autistic symptoms has still not emerged. Based on rec...

introduction: determination of type and location of trapped objects and endoscopic observations among children with foreign-body ingestion. materials and methods: we evaluated 105 endoscopic records of patients presenting with foreign-body ingestion from 2001–2011. results: button batteries were the most common objects removed (41%). the lower segment of the esophagus was the most common trappi...

background: although the need for theory-based designs, evidencesexploringexercisingeffects during pregnancy is limited by non-theoretical and cross-sectional assessments. this study aimed to prospect­ively examine women’s exercise behavior from their second to third pregnancy trimester using the health belief model (hbm).   material and methods: this was a randomized controlled trial in which ...

â  â  avicenna’s role in arabic literature â  â  nasrollah shameli * â  hamid ahmadian ** â  â  abstract â  â  the master and doyen, avicenna, is one of the prominent savants of the fourth century a.h. besides medicine and philosophy, he was a master in sciences of his time, and was proficient in arabic literature. he has peerless anthologies in poetry and prose, in both arabic and persian li...

â â â â â  bashar b. burd's atheism: reality or politics? â  â seyyed mohammad javad moosavi bafrooi * â  â abstract â many historical events demand more reflection. one of such cases is bashshar b. burd about whom there are different opinions. some people believe that he was killed because of the accusation of being atheist. however, because of the following reasons, it seems that such a ...