نتایج جستجو برای: key deletion
تعداد نتایج: 628265 فیلتر نتایج به سال:
Background The angiotensin I-converting enzyme (ACE) is a key component of the renin-angiotensin system thought to be important in the pathogenesis of hypertension and cardiovascular disease. Deletion polymorphism in the ACE gene may be a risk factor for myocardial infarction in the Caucasian population. However, this finding has not yet been investigated in the Japanese population. Methods and...
Agrobacterium tumefaciens is capable to transfer genes across kingdoms. It can genetically transform not only plant cells, but also many other bacterial, algal, fungal, animal and human cells. This depends on the interactions among a variety of both Agrobacterium and host genes. Inside the host cell, RAD52 which is involved in DNA repair is a key gene determining integration of T-DNA by homolog...
The yeast vacuole plays key roles in cellular stress responses. Here, we show that deletion of lvs1, the fission yeast homolog of the Chediak-Higashi Syndrome CHS1/LYST gene, increases vacuolar size, similar to deletion of the Rab4 homolog ypt4. Overexpression of lvs1-YFP rescued vacuolar size in ypt4Δ cells, but ypt4-YFP did not rescue lvs1Δ, suggesting that lvs1 may act downstream of ypt4. Va...
Background and Purpose Organic nitrates such as nitroglycerin (NTG) or pentaerythritol tetranitrate (PETN) have been used for over a century in the treatment of angina ischaemic heart disease. These compounds are prodrugs which release their nitrovasodilators upon enzymic bioactivation by aldehyde dehydrogenase (ALDH2) cytochromes P450 (CYP). Whereas ALDH2 is known to directly activate organic ...
Abstract Phytopathogens develop specialized infection-related structures to penetrate plant cells during infection. Different from phytopathogens that form appressoria or haustoria, the soil-borne root-infecting fungal pathogen Verticillium dahliae forms hyphopodia infection, which further differentiate into penetration pegs promote The molecular mechanisms underlying regulation of hyphopodium ...
Introduction & Objective: Male factor is the major cause of infertility in 20% of cases (WHO). There are known etiologies for 70% of cases .However, 30% of infertility cases are of idiopathic origin. The Y chromosome and micro deletion of the long arm of the Y chromosome (Yq) in three regions (AZFa, AZFb ,AZFc ) are associated with spermatogenic failure and is a major etiology for oligo and a...
Abstract Japanese has a deletion operation, called argument ellipsis, that targets arguments (Oku in A theory of selection and reconstruction the minimalist program, 1998). The operation does not apply to adjuncts, thus, adjuncts are unelidable. Funakoshi (J East Asian Linguist 25(2):113–42, 2016), following footsteps Otani Whitman (Linguist Inquiry 22:345–58, 1991), argues can be elided when V...
A well-known problem in data science and machine learning is linear regression, which recently extended to dynamic graphs. Existing exact algorithms for updating the solution of graph regression require at least a time (in terms n: size graph). However, this complexity might be intractable practice. In current paper, we utilize subsampled randomized Hadamard transformand CountSketchto propose f...
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