Bentourkia M, Tremblay S, Pifferi F, Rousseau J, Lecomte R, Cunnane S. PET study of C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis. Am J Physiol Endocrinol Metab 296: E796 –E801, 2009. First published January 27, 2009; doi:10.1152/ajpendo.90644.2008.—Normally, the brain’s fuel is glucose, but during fasting it increasingly relies on ketones ( -hydroxybutyrate, ...

PURPOSE We aimed to study whether ketogenic diet (KD) therapy leads to resolution of super-refractory status epilepticus in pediatric patients without significant harm. METHOD A retrospective review was performed at Phoenix Children's Hospital on patients with super-refractory status epilepticus undergoing ketogenic diet therapy from 2011 to 2015. RESULTS Ten children with super-refractory ...

The ketogenic diets (KDs) have been used for the treatment of medication-resistant epilepsy since the 1920s. The classical KD is a highly restrictive diet with a 3:1-4:1 ketogenic ratio, calculated as the weight of fat divided by that of carbohydrates plus protein. Although the classical KD result in at least a 50% reduction in seizure frequency in approximately half of epileptic patients, some...

We report the history of a child with autism and epilepsy who, after limited response to other interventions following her regression into autism, was placed on a gluten-free, casein-free diet, after which she showed marked improvement in autistic and medical symptoms. Subsequently, following pubertal onset of seizures and after failing to achieve full seizure control pharmacologically she was ...

BACKGROUND The increasing use of the ketogenic diet (KD), particularly by women of child-bearing age, raises a question about its suitability during gestation. To date, no studies have thoroughly investigated the direct implications of a gestational ketogenic diet on embryonic development. METHODS To fill this knowledge gap we imaged CD-1 mouse embryos whose mothers were fed either a Standard...

BACKGROUND The role of dietary restriction regimens such as caloric restriction, ketogenic diet and intermittent fasting in development of cancers has been detected via abundant preclinical experiments. However, the conclusions are controversial. We aim to review the relevant animal studies systematically and provide assistance for further clinical studies. METHODS Literatures on associations...

The enhanced capacity for long-chain fatty acid oxidation and ketogenesis that develops in the rat liver between 6 and 9 h after the onset of starvation was shown to be inducible much more rapidly by administration of anti-insulin serum or glucagon to fed rats. After only 1 h of treatment with either agent, the liver had clearly switched from a "nonketogenic" to a "ketogenic" profile, as determ...

The medium chain triglyceride (MCT) ketogenic diet is a major treatment of drug-resistant epilepsy but is problematic, particularly in adults, because of poor tolerability. Branched derivatives of octanoic acid (OA), a medium chain fat provided in the diet have been suggested as potential new treatments for drug-resistant epilepsy, but the structural basis of this functionality has not been det...

The ketogenic diet is a high-fat, low-carbohydrate, and adequate-protein diet for the treatment of intractable seizures in children, initially introduced in 1921 to mimic the biochemical changes associated with fasting. The diet is individually calculated and rigidly controlled, requiring a comprehensive medical team approach. Although there are adverse, as well as, beneficial effects, several ...