The kappa-lambda light chain ratios, the presence of free light chains and the double ring formation, with antikappa and antilambda serum, in single radial immunodiffusion were investigated in serum and cerebrospinal fluid of patients with subacute sclerosing panencephalitis. Cerebrospinal fluid samples of several multiple sclerosis cases were considered simultaneously. The results obtained sug...

A decreased concentration of immunogesting that the synthesis of molecules globulin molecules of one light chain bearing K-chains was decreased. The type (K) was found in a young girl with patient improved considerably with the recurrent respiratory infections and regular administration of 7-globulin. It diarrhea. She had, in addition, deis possible that biological as well as creased yA and yE ...

The heterogeneity of human circulating serum. In one circulating anticoagulant, anticoagulants against antihemophilic light chain specificity could not be demonfactor (AHF, factor VIII) observed in seven strated with small amounts of antiserum, patients, both with and without classic and with larger amounts, only lambda hemophilia, was investigated by neutrallight chain specificity was revealed...

In a patient with plasma cell leukemia and a kappa type Bence Jones protein in serum and urine, the immunofluorescence study of blood plasma cells showed intracellular gamma and kappa chain determinants. Biosynthesis experiments showed the production of abnormally short heavy chains (45,000 daltons) that assembled with normal sized light chains with a partial block. These abnormal heavy chains ...

The heterogeneity of human circulating serum. In one circulating anticoagulant, anticoagulants against antihemophilic light chain specificity could not be demonfactor (AHF, factor VIII) observed in seven strated with small amounts of antiserum, patients, both with and without classic and with larger amounts, only lambda hemophilia, was investigated by neutrallight chain specificity was revealed...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 43-year-old man presented with lower abdominal pain. Initial values of laboratory examinations were as follows: osteolytic lesions in the right 6 th rib and right ilium. Serum protein electrophoresis (PEP) showed no specific finding, but urine PEP revealed...

In healthy humans, 60-70% of the B lymphocytes produce kappa light chains, while the remaining cells produce lambda light chains. Malignant transformation and clonal expansion of B lymphocytes lead to an altered kappa : lambda expression ratio, which is an important diagnostic criteria of lymphomas. Here, we compared three methods for clonality determination of suspected B cell lymphomas. Tumor...

AIMS Clonality analysis using polymerase chain reaction (PCR) amplification of the immunoglobulin heavy chain (IgH) gene is an important aid to the diagnosis of B cell lymphoproliferative diseases. However, the method has a relatively high false negative rate. In an attempt to improve detection rates simple PCR strategies for clonality analysis of B cell populations using amplification of Ig li...

Antibodies bearing the T15 idiotype dominate the murine primary immune response to phosphocholine (PC). Analysis of antigen binding of antibodies derived from V1:DFL16.1:JH1 (VH1) germline and N region-derived variant heavy (H) chains and kappa 22, kappa 24, and kappa 8 light (L) chains demonstrates that the T15H:kappa 22L (T15) antibody binds PC at least 20-40 times better than other antibodie...