Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigote...

In this paper, the dynamics and control of a novel mobile robot on the International Space Station (ISS) are discussed. The Japan Aerospace Exploration Agency (JAXA) is developing a robotic system which has an extendable arm and several tethers to support Extravehicular Activity (EVA) performed by astronauts. The robotic arm is build from a light material and can be extended longer. The vibrati...

We discuss the INTEGRAL capabilities to detect a high redshift population of gamma-ray bursts (GRBs). First a simple comparison between other past or planned experiments (BATSE, SAX, HETE-2, Rømer, Swift) and INTEGRAL instrumentation (IBIS, JEM-X) is shown. After this first view we will be focused on comparing the capabilities of the two most sensitive missions (INTEGRAL/IBIS and Swift) of dete...

The EUSO-Balloon is a pathfinder of the JEM-EUSO mission, designed to be installed on-board the International Space Station before the end of this decade. The EUSO-Balloon instrument, conceived as a scaleddown version of the main mission, is currently developed as a payload of a stratospheric balloon operated by CNES, and will, most likely, be launched during the CNES flight campaign in 2014. S...

JEM © The Rockefeller University Press $30.00 Vol. 205, No. 4, April 14, 2008 967-979 www.jem.org/cgi/doi/ 967 10.1084/jem.20072051 Rheumatoid arthritis (RA) is a chronic disease aff ecting the peripheral joints in which abnormalities in the synovium precipitate a destructive process that often leads to cartilage and bone erosion. The autoimmune nature of this disease has been defi ned, in part...

The Rockefeller University Press $30.00 J. Exp. Med. www.jem.org/cgi/doi/10.1084/jem.20080421 Cite by DOI: 10.1084/jem.20080421 1 of 19 The mechanism resulting in increased numbers of microglia in the central nervous system (CNS) during infl ammation has long been debated. Microglia have been shown to proliferate in situ in several synthetic infl ammatory models ( 1 – 4 ). In contrast, it is su...