Studies in humans and rats suggest that intrauterine growth retardation (IUGR) permanently resets the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis reprogramming may involve persistently altered expression of the hippocampal glucocorticoid receptor (hpGR), an important regulator of HPA axis reactivity. Persistent alteration of gene expression, long after the inciting event, is thought to ...

Intrauterine growth restriction (IUGR) programs adult disease, including obesity and insulin resistance. Our group previously demonstrated that IUGR dysregulates adipose deposition in male, but not female, weanling rats. Dysregulated adipose deposition is often accompanied by the release of proinflammatory signaling molecules, such as tumor necrosis factor alpha (TNF α ). TNF α contributes to a...

مقدمه الیگوهیدرامنیوس می تواند عوارض متعدد جنینی را به همراه داشته باشد و از طرفی محدودیت رشد داخل رحمی (iugr) یکی از علل مهم الیگوهیدرامنیوس است. هدف از این مطالعه مقایسه پیامد های بارداری در حاملگی های با الیگوهیدرامنیوس ایزوله و همراه با iugr است. روش کار این مطالعه به صورت همگروهی در 60 زن 18 تا 35 ساله که در سونوگرافی سنجش ایندکس مایع امنیوتیک، کمتر از 5 گزارش شده بود انجام گرفت. افراد به ...

Intrauterine growth restriction (IUGR) is one of the major causes of perinatal mortality and morbidity. Pregnancies with IUGR are associated with an altered lipid profile which in turn affects the fetal growth. The study was conducted on 60 age matched female individuals divided into three groups. Group A consisted of 20 normal pregnant women,Group B was formed by 20 women diagnosed as IUGR pre...

We recently reported that epidermal growth factor (EGF) levels in the first urine to be voided by intrauterine growth retardation (IUGR) and heavy-for-dates (HFD) infants were lower than control infants (8). In this study, we analyzed EGF receptors to reveal the mechanisms controlling EGF levels. EGF binding to fetal rat liver increased markedly from day 19-21 of gestation. Fetal rats were divi...

Intrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI), a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to delivery, the doubly clamped umbilical cords (representing fetal state), and their 20 IUGR and 20 appropriate-for-gestational-age (A...

Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in later life. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine growth retardation, in the rat. Early in life, the animals are insulin resistant and by 6 mo of age they develop diabetes. Glycogen content and insulin-stimulated 2-deoxyglucose uptake were significa...

Gross and microscopic examination was conducted on one hundred placentas. These included twenty five normal controls and seventy five from intrauterine growth retardation (IUGR) pregnancies. Weight of the placentas from IUGR pregnancies were less than those of normal placentas. The incidence of infarction, intervillous fibrin deposition were much higher in IUGR placentas on gross examination. H...

In this study, we examined chronic norepinephrine suppression of insulin secretion in sheep fetuses with placental insufficiency-induced intrauterine growth restriction (IUGR). Glucose-stimulated insulin secretion (GSIS) was measured with a square-wave hyperglycemic clamp in the presence or absence of adrenergic receptor antagonists phentolamine (alpha) and propranolol (beta). IUGR fetuses were...

Low birth weight is associated with an increased risk of hypertension and renal dysfunction at adulthood. Such an association has been shown to involve a reduction of nephron endowment and to be enhanced by accelerated postnatal growth in humans. However, while low-birth-weight infants often undergo catch-up growth, little is known about the long-term vascular and renal effects of accelerated p...