BACKGROUND Oral isotretinoin is highly effective in all forms and grades of acne, even in lower dosages (<0.5 mg/kg/day). There is a paucity of comparative data on the various low-dose regimens of oral isotretinoin in the Indian literature. OBJECTIVES To assess and compare the efficacy and tolerability of two low-dose oral isotretinoin treatment regimens (20 mg daily and 20 mg alternate days)...

The prolonged use of retinoids is associated with changes in bone turnover markers and toxic skeletal effects. Although the effect of short-term oral isotretinoin therapy on bone loss is not well established, caution is recommended when it is used in patients with metabolic bone disease. We examined prospectively the effect of short-term oral isotretinoin therapy on bone turnover markers and bo...

Isotretinoin, commonly known as 13-cis-retinoic acid, is a vitamin derivative used to treat severe acne and several types of skin, head, neck cancer. According certain research, isotretinoin causes apoptosis in number different bodily cells. In instances clinically obvious acute liver injury with jaundice, has not been definitively linked. It unknown how elevates serum aminotransferase levels, ...

BACKGROUND Adverse changes in bone have been reported for patients undergoing high-dose, long-term (several years) isotretinoin therapy for disorders of cornification. The effect of short-term (4-5 months) therapy at the lower dose recommended for acne on bone development in younger, growing adolescent (12-17 years) patients has not been well studied. OBJECTIVE The purpose of the study was to...

BACKGROUND Within the plastic surgery community, it is widely believed that waiting a minimum of 6 to 12 months after patient cessation of systemic retinoid therapy is necessary before proceeding with elective surgery. OBJECTIVE The authors investigate partial- and full-thickness wound healing after treatment with systemic isotretinoin in a porcine model. METHODS Following institutional app...

Report of Cases | Case 1. A female patient in her teens presentedwith a 2-year history of severe, nodular, cystic acne of her face (Figure 1A), chest, and backwith significant scarring. Herhormonalworkupwasunrevealing. Twoyears earlier, she had receivedminocycline for acne and had developed an unusually severe headache; lumbar puncture confirmed PTC. Promptdiscontinuationofminocycline treatment...

Background. Although isotretinoin orally is commonly used for moderate to severe or scarring acne, it is not a cure. Unfortunately recurrence is unpredictable and varies within the acne population. Objectives. Using a proof of concept study, determine the recurrence of acne after isotretinoin use in male patients. Methods. Twenty males aged 18-45 years old were enrolled. Subjects successfully c...

PURPOSE The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. METHODS Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with ...