Exhaled breath condensate (EBC) has been increasingly used as a new and non-invasive method to study airway inflammation. In this study we have compared the concentrations of lipid mediators in EBC with concentrations in bronchoalveolar lavage fluid (BALF). We included 37 patients undergoing bronchoscopy (12 sarcoidosis, 12 COPD, 6 lung cancer, 5 chronic cough, 1 Wegener's granulomatosis, 1 scl...

Cardioplegic arrest for bypass surgery imposes global ischemia on the myocardium, which generates oxyradicals and depletes myocardial high-energy phosphates. The glycolytic metabolite pyruvate, but not its reduced congener lactate, increases phosphorylation potential and detoxifies oxyradicals in ischemic and postischemic myocardium. This study tested the hypothesis that pyruvate mitigates oxid...

OBJECTIVES Both chronic kidney disease (CKD) and hemodialysis (HD) are reported to elevate oxidative stress. Available evidence for oxidative stress is indirect measurement of oxidative stress as accumulation of byproducts by reactive oxygen species (ROS). We aimed to examine the effect of CKD and HD on ROS levels in circulating leukocytes and to compare those with conventional oxidative stress...

Background Metabolic syndrome (MS), a condition related to adiposity and oxidative stress, can develop in adolescence, critical stage life that impacts health adulthood. However, there is scarce scientific research about the relationship between lifestyle factors, emotion management, stress this phase of life. Aim To analyze whether nutritional parameters, MS adolescents are associated with mea...

BACKGROUND AND AIM: 15-F2t-Isoprostane is a product of arachidonic acid non-enzymatic oxidation by free radicals. Validated in animal and clinical models, it golden standard tool for the oxidative status assessment. The aim this study to assess how biomarker levels could vary during lifespan. METHODS: urinary concentration was measured 889 subjects aged between 7 69. analyses were performed ELI...

Ginger L. Milne, Huiyong Yin, and Jason D. Morrow Division of Clinical Pharmacology, Departments of Medicine and Pharmacology Vanderbilt University School of Medicine, 23 Avenue South at Pierce Avenue, Nashville, TN 37232-6602 Address correspondence to: Jason D. Morrow M.D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, 23...

OBJECTIVE To estimate the prevalence of DR and to correlate cardiometabolic, sociodemographic, and oxidant/antioxidant imbalance data to the prevalence of DR. DESIGN This case-control study included type 2 DM (T2 DM) patients with DR (n = 66), T2 DM patients without DR (N = 84), and healthy controls (n = 45) without DR, in Kinshasa town. Diet, albuminemia, serum vitamins, and 8-isoprostane we...

INTRODUCTION The lipid composition of the sperm membrane has a significant effect on the functional characteristics of spermatozoa. PATIENTS AND METHODS In the present study, fatty acid composition of spermatozoa and seminal plasma levels of free 15-F(2t)-Isoprostane and catalase were assayed in men with normozoospermia, asthenozoospermia, asthenoteratozoospermia, and oligoasthenoteratozoospe...